Department of Pain Medicine and Shenzhen Municipal Key Laboratory for Pain Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital, 89 Taoyuan Ave, Nanshan District, Shenzhen, 518000. Guangdong Province, China.
Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, School of Biomedical Engineering, Shenzhen University Health Science Center, 1066 Xueyuan Avenue, Nanshan District, Shenzhen, 518060 Guangdong Province, China.
Biomed Res Int. 2022 Sep 17;2022:1960244. doi: 10.1155/2022/1960244. eCollection 2022.
This systematic review and meta-analysis aimed to compare the diagnostic performance of transient elastography (TE) and two-dimensional shear wave elastography (2D-SWE) for staging liver fibrosis in patients with chronic viral hepatitis (CVH).
Pubmed, Embase, Web of Science, and Cochrane Library were searched (-01/08/2021) for studies comparing TE with 2D-SWE in patients with CVH. Other etiologies of chronic liver disease (CLD) and articles not published in SCI journals were excluded. The bivariate random-effects model was used to pool the performance of the TE and 2D-SWE.
Eight articles with a total of 1301 CVH patients were included. The prevalence of significant fibrosis (fibrosis stage ≥ 2), advanced fibrosis (fibrosis stage ≥ 3), and cirrhosis was 50.8%, 44.8%, and 34.7%, respectively. 2D-SWE expressed higher overall accuracy than TE in detecting significant fibrosis (0.93 vs. 0.85, = 0.04). No significant difference among the overall diagnostic accuracy of TE and 2D-SWE in staging advanced fibrosis and cirrhosis was found.
TE and 2D-SWE express good to excellent diagnostic accuracies to stage fibrosis in CVH patients. 2D-SWE compares favorably with TE especially for predicting significant fibrosis.
本系统评价和荟萃分析旨在比较瞬时弹性成像（TE）和二维剪切波弹性成像（2D-SWE）在诊断慢性病毒性肝炎（CVH）患者肝纤维化分期中的诊断性能。
检索 Pubmed、Embase、Web of Science 和 Cochrane Library 以获取比较 CVH 患者 TE 与 2D-SWE 的研究。排除其他慢性肝病（CLD）病因和未发表在 SCI 期刊上的文章。采用双变量随机效应模型对 TE 和 2D-SWE 的性能进行汇总。
共纳入 8 篇文章，总计 1301 例 CVH 患者。显著纤维化（纤维化分期≥2）、进展性纤维化（纤维化分期≥3）和肝硬化的患病率分别为 50.8%、44.8%和 34.7%。2D-SWE 在检测显著纤维化方面的总体准确性高于 TE（0.93 比 0.85，=0.04）。TE 和 2D-SWE 在分期进展性纤维化和肝硬化方面的总体诊断准确性之间没有显著差异。
TE 和 2D-SWE 对 CVH 患者的纤维化分期具有良好至极好的诊断准确性。2D-SWE 与 TE 相比，尤其在预测显著纤维化方面具有优势。
