Xu Si-Min, Dai Ze-Qi, Wu Xue, Li Miao-Miao, Liao Xing
Center for Evidence-based Chinese Medicine, Institute of Basic Research in Clinical Medicine,China Academy of Chinese Medical Sciences Beijing 100700, China.
Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences Beijing 100700, China.
Zhongguo Zhong Yao Za Zhi. 2022 Sep;47(17):4778-4788. doi: 10.19540/j.cnki.cjcmm.20220520.501.
This study evaluated and compared the efficacy, safety and economy of four Chinese patent medicines(CPMs) in the treatment of functional dyspepsia(FD) using the method of rapid health technology assessment. It aims to provide decision-makers with rapid decision-making information. The eight Chinese and English databases were comprehensively and systematically searched for the relevant clinical research. Studies were screened and evaluated. A total of 110 studies were identified, including 95 randomized controlled trials(RCTs), 7 controlled clinical trials(CCTs), 7 systematic review/Meta-analysis and 1 economic evaluation, among which 28 were Dalitong Granules, 49 were Zhizhu Kuanzhong Capsules, 3 were Biling Weitong Granules and 30 were Qizhi Weitong Granules(Tablets/Capsules). The quality of the included literature was generally low. The efficacy of four CPMs alone or combined with western medicine in the treatment of FD is different. Dalitong Granules was used to treat motility disorder in FD. Zhizhu Kuanzhong Capsules and Qizhi Weitong Granules(Tablets/Capsules) can treat FD patients with anxiety and depression. Qizhi Weitong Granules(Tablets/Capsules) were mainly used in FD for perimenopausal patients. There were no serious adverse reactions in the clinical study of four CPMs in the treatment of FD. Dalitong Granules has better effects than mosapride in the treatment of FD, but the cost is slightly higher. The cost-effectiveness ratio of Zhizhu Kuanzhong Capsules in the treatment of FD patients with anxiety and depression was lower than that of Domperidone. In terms of average daily price, Qizhi Weitong Tablets has the highest price(27.00 yuan per day), Qizhi Weitong Granules has the lowest price(5.04 yuan per day), Biling Weitong Granules has a relatively high price(15.53 yuan per day), followed by Dalitong Granules(13.03 yuan per day). The evidence of Dalitong Granules covered the efficacy, safety and economy, which is relatively complete compared with the other three drugs. It has effective potential in the treatment of motility disorder in FD. Further research in this field in the future is needed.
本研究采用快速卫生技术评估方法，对四种中成药治疗功能性消化不良（FD）的疗效、安全性和经济性进行了评估和比较。旨在为决策者提供快速决策信息。全面系统检索了八个中英文数据库中的相关临床研究。对研究进行筛选和评估。共纳入110项研究，包括95项随机对照试验（RCT）、7项对照临床试验（CCT）、7项系统评价/Meta分析和1项经济评价，其中达立通颗粒28项、枳术宽中胶囊49项、必灵胃通颗粒3项、气滞胃痛颗粒（片/胶囊）30项（表1）。纳入文献质量普遍较低。四种中成药单独或联合西药治疗FD的疗效不同。达立通颗粒用于治疗FD的动力障碍。枳术宽中胶囊和气滞胃痛颗粒（片/胶囊）可治疗伴有焦虑抑郁的FD患者。气滞胃痛颗粒（片/胶囊）主要用于围绝经期FD患者。四种中成药治疗FD的临床研究中均未出现严重不良反应。达立通颗粒治疗FD的效果优于莫沙必利，但费用略高。枳术宽中胶囊治疗伴有焦虑抑郁的FD患者的成本效益比低于多潘立酮。就日均价格而言，气滞胃痛片最高（每日27.00元），气滞胃痛颗粒最低（每日5.04元），必灵胃通颗粒价格相对较高（每日15.53元），其次是达立通颗粒（每日13.03元）。达立通颗粒的证据涵盖了疗效、安全性和经济性，与其他三种药物相比相对完整。其在治疗FD动力障碍方面具有有效潜力。未来需要在该领域进一步研究。
