高迁移率族蛋白 1 和 Dickkopf 相关蛋白 1 作为 2 型糖尿病患者糖毒性、动脉粥样硬化性和胰岛β细胞功能降低的生物标志物。

High mobility group box 1 and Dickkopf-related protein 1 as biomarkers of glucose toxicity, atherogenicity, and lower β cell function in patients with type 2 diabetes mellitus.

机构信息

Department of Chemistry, College of Science, University of Kufa, Kufa, Iraq.

Laboratories Division, Maysan Health Department, Misan Governorate, Misan, Iraq.

出版信息

Growth Factors. 2022 Nov;40(5-6):240-253. doi: 10.1080/08977194.2022.2126317. Epub 2022 Sep 27.

DOI:10.1080/08977194.2022.2126317

PMID:36165005

Abstract

Type 2 diabetes mellitus (T2DM) is associated with increased atherogenicity and inflammatory responses, which may be related to high mobility group box 1 (HMGB1) and Dickkopf-related protein 1 (DKK1). The role of HMGB1 and DKK1 in T2DM is examined in association with lipid and insulin profiles. Serum HMGB1 and DKK1 were measured in T2DM with and without hypertension and compared with controls. The results showed that HMGB1 and DKK1 are higher in T2DM irrespective of hypertension. A large part of the variance in the β-cell index and glucose toxicity was explained by the combined effects of HMGB1 and DKK1. In conclusion, both HMGB1 and DKK1 may contribute to increased atherogenicity in T2DM. Moreover, both biomarkers may cause more deficits in β-cell function and increase glucose toxicity leading to the development of more inflammation and diabetic complications. HMGB1 and the Wnt pathways are other drug targets in treating T2DM.

摘要

2 型糖尿病（T2DM）与动脉粥样硬化性和炎症反应增加有关，这可能与高迁移率族蛋白 B1（HMGB1）和 Dickkopf 相关蛋白 1（DKK1）有关。研究了 HMGB1 和 DKK1 与脂质和胰岛素谱的关系在 T2DM 中的作用。在有或没有高血压的情况下测量了 T2DM 患者的血清 HMGB1 和 DKK1，并与对照组进行了比较。结果表明，HMGB1 和 DKK1 在 T2DM 中无论是否存在高血压均升高。β细胞指数和葡萄糖毒性的大部分差异可以用 HMGB1 和 DKK1 的联合作用来解释。总之，HMGB1 和 DKK1 可能导致 T2DM 中动脉粥样硬化性增加。此外，这两种生物标志物都可能导致β细胞功能更多的丧失，并增加葡萄糖毒性，从而导致更多的炎症和糖尿病并发症的发生。HMGB1 和 Wnt 通路是治疗 T2DM 的其他药物靶点。