Wang Hang, Qu Hua, Deng Huacong
M.D. Department of Endocrinology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
PLoS One. 2015 Aug 28;10(8):e0136564. doi: 10.1371/journal.pone.0136564. eCollection 2015.
To detect the levels of plasma High-Mobility Group Box-1(HMGB1) in Chinese subject with obesity and type 2 diabetes mellitus (T2DM), and to investigate the correlations between plasma HMGB1 concentration and parameters of body fat, insulin resistance (IR) metabolism and inflammation.
This study recruited 79 normal glucose tolerance (NGT) subjects and 76 newly diagnosed T2DM patients. NGT and T2DM groups were divided into normal weight (NW) and obese (OB)subgroups respectively. Anthropometric parameters such as height, weight, waist circumference, hip circumference and blood pressure were measured. Plasma concentrations of HMGB1, IL-6, fasting plasma glucose (FPG), 2 hours post challenge plasma glucose (2hPG), serum lipid, glycated hemoglobin (HbA1C) and fasting insulin (FINS) were examined. The homeostasis model assessment (HOMA) was performed to assess IR status.
Plasma HMGB1 levels were higher in T2DM group than that in NGT group. The concentrations of serum HMGB1 were also higher in subjects with OB than those in subjects with NW both in NGT and T2DM groups. Plasma levels of HMGB1 were positively correlated with waist hip ratio (WHR), blood pressure, FPG, FINS, HOMA-IR, TG, IL-6 and negatively correlated with HOMA-βand high-density lipoprotein-cholesterol (HDL-c) independent of age, gender and BMI. Plasma levels of HMGB1 were significantly correlated with diabetes in fully adjusted models.
Plasma HMGB1 levels were increased in Chinese subjects with pure T2DM, which might be caused by IR. Serum HMGB1 participated in the pathological process of obesity and T2DM via its proinflammatory effect.
检测中国肥胖合并2型糖尿病（T2DM）患者血浆高迁移率族蛋白B1（HMGB1）水平，探讨血浆HMGB1浓度与体脂、胰岛素抵抗（IR）代谢及炎症参数之间的相关性。
本研究招募了79例糖耐量正常（NGT）受试者和76例新诊断的T2DM患者。NGT组和T2DM组分别分为正常体重（NW）和肥胖（OB）亚组。测量身高、体重、腰围、臀围和血压等人体测量参数。检测血浆HMGB1、IL-6、空腹血糖（FPG）、餐后2小时血糖（2hPG）、血脂、糖化血红蛋白（HbA1C）和空腹胰岛素（FINS）浓度。采用稳态模型评估（HOMA）来评估IR状态。
T2DM组血浆HMGB1水平高于NGT组。在NGT组和T2DM组中，OB受试者的血清HMGB1浓度也高于NW受试者。血浆HMGB1水平与腰臀比（WHR）、血压、FPG、FINS、HOMA-IR、甘油三酯（TG）、IL-6呈正相关，与HOMA-β和高密度脂蛋白胆固醇（HDL-c）呈负相关，且不受年龄、性别和体重指数（BMI）的影响。在完全调整模型中，血浆HMGB1水平与糖尿病显著相关。
中国单纯T2DM患者血浆HMGB1水平升高，可能由IR引起。血清HMGB1通过其促炎作用参与肥胖和T2DM的病理过程。
