Department of Pediatric Intensive Care Unit, The First Hospital of Jilin University, Jilin, China.
Ther Apher Dial. 2023 Apr;27(2):197-206. doi: 10.1111/1744-9987.13934. Epub 2022 Oct 12.
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is the most commonly identified cause of autoimmune encephalitis. Therapeutic plasma exchange has been increasingly employed to treat this disease. This expansion is a consequence of improved techniques and apheresis instruments, as well as the recognition of its applicability in neurological diseases. However, several aspects of treatment remain incompletely clarified, and treatment strategies are still heterogeneous, especially with regard to therapeutic plasma exchange in anti-NMDAR encephalitis. This review provides an overview of the use of therapeutic plasma exchange including the principle and mechanisms, the evidence, initial time, efficiency and complications in anti-NMDAR encephalitis.
抗 N-甲基-D-天冬氨酸受体（anti-NMDAR）脑炎是最常见的自身免疫性脑炎病因。治疗性血浆置换已越来越多地用于治疗这种疾病。这种扩张是由于技术和血浆分离仪器的改进，以及对其在神经疾病中的适用性的认识所致。然而，治疗的几个方面仍未完全阐明，治疗策略仍存在异质性，特别是在抗 NMDAR 脑炎的治疗性血浆置换方面。这篇综述概述了治疗性血浆置换的应用，包括在抗 NMDAR 脑炎中的原理和机制、证据、起始时间、疗效和并发症。
