Department of Pneumology, The Second People's Hospital of Hunan Province (Brain Hospital of Hunan Province), Changsha, China.
Department of Nephrology, The Third Xiangya Hospital of Central South University, Changsha, China.
Genet Test Mol Biomarkers. 2022 Sep;26(9):430-442. doi: 10.1089/gtmb.2022.0068.
This study was designed to evaluate the association between macrophage migration inhibitory factor () gene polymorphisms, serum MIF levels and tuberculosis (TB) susceptibility. All satisfactory studies were included; the genotype number and serum MIF levels were reviewed. The Stata and Review Manager software were used for the pooled analyses. The pooled analyses showed that the -173G/C gene polymorphism was associated with TB (allele C vs allele G: odds ratio (OR) = 1.44, 95% confidence interval (CI): 1.28-1.62, < 0.01; genotype CC vs genotype GG: OR = 1.69, 95% CI: 1.05-2.73, = 0.03; genotype CC+GC vs genotype GG: OR = 1.56, 95% CI: 1.34-1.81, < 0.01; genotype GC vs genotype GG: OR = 1.50, 95% CI: 1.28-1.75, < 0.01). The subgroup analysis showed that the -173G/C gene polymorphism was significantly associated with the risk of both pulmonary tuberculosis (PTB) and spinal tuberculosis (STB).The CATT-794 gene polymorphism was associated with the PTB susceptibility in Asian subjects (genotypes 5/X+6/X vs genotypes 7/X+8/X: OR = 0.39, 95% CI: 0.24-0.64, < 0.01; genotypes 5 + 6 vs genotypes 7 + 8: OR = 0.57, 95% CI: 0.48-0.69, < 0.01). Both PTB and STB patients had significantly elevated serum MIF levels compared to healthy controls. The -173G/C gene polymorphism is related to both PTB and STB susceptibility in both Asian and Caucasian populations. The C allele and CC genotype of the -173G/C SNP appear to be TB risk factors. The CATT-794 gene polymorphism is associated with the PTB susceptibility in Asian subjects; serum MIF levels were significantly increased in PTB and STB patients.
本研究旨在评估巨噬细胞移动抑制因子（MIF）基因多态性、血清 MIF 水平与结核病（TB）易感性之间的关系。纳入所有符合条件的研究；对基因型数量和血清 MIF 水平进行了综述。采用 Stata 和 Review Manager 软件进行汇总分析。汇总分析显示，-173G/C 基因多态性与 TB 相关（等位基因 C 与等位基因 G：比值比（OR）=1.44，95%置信区间（CI）：1.28-1.62， < 0.01；基因型 CC 与基因型 GG：OR=1.69，95%CI：1.05-2.73， = 0.03；基因型 CC+GC 与基因型 GG：OR=1.56，95%CI：1.34-1.81， < 0.01；基因型 GC 与基因型 GG：OR=1.50，95%CI：1.28-1.75， < 0.01）。亚组分析显示，-173G/C 基因多态性与肺结核（PTB）和脊柱结核（STB）的发病风险显著相关。-173G/C 基因多态性与亚洲人群 PTB 易感性相关（基因型 5/X+6/X 与基因型 7/X+8/X：OR=0.39，95%CI：0.24-0.64， < 0.01；基因型 5+6 与基因型 7+8：OR=0.57，95%CI：0.48-0.69， < 0.01）。与健康对照组相比，PTB 和 STB 患者的血清 MIF 水平均显著升高。-173G/C 基因多态性与亚洲和高加索人群的 PTB 和 STB 易感性均相关。-173G/C SNP 的 C 等位基因和 CC 基因型似乎是 TB 的危险因素。-173G/C 基因多态性与亚洲人群的 PTB 易感性相关；PTB 和 STB 患者的血清 MIF 水平显著升高。
