Oniris, INRAE, LABERCA, F44300, Nantes, France.
ANSES, Laboratory for Food Safety, University of Paris-Est, 94700, Maisons-Alfort, France.
Chemosphere. 2022 Dec;308(Pt 3):136563. doi: 10.1016/j.chemosphere.2022.136563. Epub 2022 Sep 24.
There has been a recent revival of interest in some historical contaminants such as polychlorinated naphthalenes (PCNs). However, occurrence data are still lacking in some countries although industrial production of PCNs has been reported. This observation led to the first ever assessment of their presence in fish and seafood products in France in the present work. Their analysis was integrated in an already validated method applied for polychlorinated dibenzodioxins/furans (PCDD/Fs) and polychlorinated biphenyls (PCBs), based on the structural similarity existing between these POPs. Performances of the method (LODs in the range 0.10-0.28 pg g wet weight (ww), LOQs in the range 0.33-0.93 pg g ww), enabled monitoring 69 di-to octachlorinated congeners in a large representative set of fish and seafood samples collected in 2005 in four coastal areas of the French mainland (n > 30). Their systematic presence was demonstrated in all the investigated seafood products, with levels (ΣPCNs in the range 2-440 pg g wet weight) close to those already reported in other European fish and seafood sampled at a similar period. In addition, the robust measurement of almost all possible PCNs (69/75) allowed a fine interpretation of the observed profiles, highlighting in particular the specificities between species and fishing areas. Compared to the PCDD/Fs, PCBs, and polybrominated diphenylethers levels also measured for this set of samples, PCNs were observed as minor contributors to total concentrations (0.05-3.2%). The specific PCN related dietary dioxin-like exposure could be evaluated at 0.028-0.051 pg of toxic equivalent (TEQ) per kg of body weight per week for an adult, based on fish and seafood consumption only. Overall, this study provides the first baseline data on the occurrence of a large number of PCNs in France, which will allow future evaluation of temporal trends and associated risks.
最近人们对某些历史污染物（如多氯萘（PCNs））重新产生了兴趣。然而，尽管已报道 PCN 的工业生产，但在一些国家仍缺乏相关的出现数据。这一观察结果促使人们首次在法国对鱼类和海鲜产品中 PCNs 的存在情况进行评估。在本工作中，PCNs 的分析被整合到了一种已经经过验证的方法中，该方法用于多氯二苯并对二恶英/呋喃（PCDD/Fs）和多氯联苯（PCBs）的分析，其依据是这些持久性有机污染物之间存在的结构相似性。该方法的性能（检测限在 0.10-0.28 pg g 湿重（ww）范围内，定量限在 0.33-0.93 pg g ww 范围内）使得能够在 2005 年法国大陆四个沿海地区采集的大量代表性鱼类和海鲜样本中监测到 69 种二至八氯同系物（n > 30）。所有被调查的海鲜产品中都系统地存在这些物质，其含量（ΣPCNs 范围为 2-440 pg g 湿重）与同期在其他欧洲鱼类和海鲜中报道的含量相近。此外，几乎所有可能的 PCN（69/75）都被准确地测量到，这使得对所观察到的分布情况进行了精细的解释，特别突出了不同物种和捕捞区之间的特异性。与 PCDD/Fs、PCBs 和多溴二苯醚的水平相比，在对这组样本的测量中，PCNs 被认为是总浓度（0.05-3.2%）的次要贡献者。基于鱼类和海鲜的消费，仅通过 PCN 相关的饮食二恶英样暴露，就可评估成人每周每公斤体重 0.028-0.051 pg 的毒性当量（TEQ）。总的来说，本研究提供了法国大量 PCN 存在情况的首批基线数据，这将有助于未来评估时间趋势和相关风险。
