Department of Occupational Health, School of Public Health, 48439Tehran University of Medical Sciences, Tehran, Iran.
Student research committee, Shiraz University of Medical Sciences, Shiraz, Iran.
Toxicol Ind Health. 2022 Nov;38(11):757-772. doi: 10.1177/07482337221129162. Epub 2022 Sep 27.
Prostate Cancer (PCa) is the second most common hormone-sensitive neoplasm among men and the fifth cause of death due to malignancy in developed countries. Moreover, studies have shown the links between polychlorinated biphenyls (PCBs) and hormone-related cancers such as prostate cancer. Hence, we conducted a systematic review and meta-analysis to evaluate the potential relationship between the PCBs and developing PCa. In this meta-analysis study, the relevant databases such as Web of Science, PubMed, and Scopus were studied for English research. The Newcastle-Ottawa Scale was applied to evaluate the quality of the selected publications. The GRADE method was used to assess the risk of bias studies. After reviewing the relevant studies, a cohort and seven case-control studies entered the meta-analysis. These articles were published during 2003-2021 with 2989 participants and 1212 PCa cases. The heterogeneity among the studies was significant ( = 0.001, I = 70.61). Using a random-effects model, the association between the serum and plasma levels of PCBs and the risk of PCa was not shown to be significant (OR = 1.12; 95% CI: 0.90-1.39). The results of Egger's test showed no trace of publication bias in the studies (P of bias = 0.573). This systematic review and meta-analysis was presented based on relatively strong evidence and has confirmed negatively significant associations between PCa risk and some PCBs congeners (PCB 44, 52, and 101). This study does not provide strong evidence that total PCB exposure is a risk factor for PCa development in humans.
前列腺癌（PCa）是男性中第二常见的激素敏感性肿瘤，也是发达国家中第五大因恶性肿瘤导致的死亡原因。此外，研究表明多氯联苯（PCBs）与前列腺癌等激素相关癌症之间存在关联。因此，我们进行了系统评价和荟萃分析，以评估 PCBs 与前列腺癌发展之间的潜在关系。在这项荟萃分析研究中，我们研究了 Web of Science、PubMed 和 Scopus 等相关数据库中的英文研究。应用纽卡斯尔-渥太华量表（Newcastle-Ottawa Scale）来评估所选出版物的质量。使用 GRADE 方法评估研究偏倚的风险。在审查了相关研究后，一项队列研究和七项病例对照研究进入了荟萃分析。这些文章发表于 2003-2021 年，共有 2989 名参与者和 1212 例前列腺癌病例。研究之间存在显著的异质性（ = 0.001，I = 70.61）。使用随机效应模型，未显示血清和血浆中 PCBs 水平与前列腺癌风险之间存在显著关联（OR = 1.12；95% CI：0.90-1.39）。Egger 检验结果表明，研究中没有发表偏倚的痕迹（偏倚 P = 0.573）。本系统评价和荟萃分析基于相对较强的证据，证实了某些 PCBs 同系物（PCB 44、52 和 101）与前列腺癌风险之间存在负显著关联。本研究并未提供强有力的证据表明总 PCB 暴露是人类前列腺癌发展的危险因素。
