Raha C R, Cheung M S, Bresnick E
Toxicol Lett. 1987 Aug;37(3):229-33. doi: 10.1016/0378-4274(87)90136-6.
6-Nitrobenzo[alpha]pyrene (6-NBaP) occurs in our environment. Since human exposure to environmental contaminants may occur via the inhalation route, we examined the metabolites of 6-NBaP formed in lung preparations, and compared the metabolite profile to that which was found with liver. The metabolites formed in both liver and lung preparations consisted of ring-hydroxylated 6-NBaP, 6-hydroxybenzo[a]pyrene (6-OHBaP) and small amounts of benzo[a]pyrene. In the lung experiments, 6-OHBaP most frequently oxidized to quinones. The mechanism for the formation of 6-OHBaP from 6-NBaP remains to be elucidated.
6-硝基苯并[a]芘（6-NBaP）存在于我们的环境中。由于人类可能通过吸入途径接触环境污染物，我们研究了在肺组织制剂中形成的6-NBaP的代谢产物，并将代谢产物谱与在肝脏中发现的进行了比较。肝脏和肺组织制剂中形成的代谢产物包括环羟基化的6-NBaP、6-羟基苯并[a]芘（6-OHBaP）和少量的苯并[a]芘。在肺部实验中，6-OHBaP最常氧化为醌。从6-NBaP形成6-OHBaP的机制仍有待阐明。
