Liu Xiyu, Sun Shuoshuo, Wang Nan, Kang Ran, Xie Lin, Liu Xin
Third School of Clinical Medicine, Nanjing University of Traditional Chinese Medicine, Nanjing, China.
Department of Orthopedics, Nanjing Lishui Hospital of Traditional Chinese Medicine, Nanjing, China.
Front Bioeng Biotechnol. 2022 Sep 12;10:998988. doi: 10.3389/fbioe.2022.998988. eCollection 2022.
Bone-related diseases caused by trauma, infection, and aging affect people's health and quality of life. The prevalence of bone-related diseases has been increasing yearly in recent years. Mild bone diseases can still be treated with conservative drugs and can be cured confidently. However, serious bone injuries caused by large-scale trauma, fractures, bone tumors, and other diseases are challenging to heal on their own. Open surgery must be used for intervention. The treatment method also faces the problems of a long cycle, high cost, and serious side effects. Studies have found that hydrogels have attracted much attention due to their good biocompatibility and biodegradability and show great potential in treating bone-related diseases. This paper mainly introduces the properties and preparation methods of hydrogels, reviews the application of hydrogels in bone-related diseases (including bone defects, bone fracture, cartilage injuries, and osteosarcoma) in recent years. We also put forward suggestions according to the current development status, pointing out a new direction for developing high-performance hydrogels more suitable for bone-related diseases.
由创伤、感染和衰老引起的骨相关疾病影响着人们的健康和生活质量。近年来，骨相关疾病的患病率逐年上升。轻度骨疾病仍可用保守药物治疗，且有望治愈。然而，由大规模创伤、骨折、骨肿瘤等疾病引起的严重骨损伤自行愈合具有挑战性，必须采用开放手术进行干预。这种治疗方法还面临周期长、成本高和副作用严重等问题。研究发现，水凝胶因其良好的生物相容性和生物降解性而备受关注，在治疗骨相关疾病方面显示出巨大潜力。本文主要介绍了水凝胶的性质和制备方法，综述了近年来水凝胶在骨相关疾病（包括骨缺损、骨折、软骨损伤和骨肉瘤）中的应用。我们还根据当前的发展状况提出了建议，为开发更适合骨相关疾病的高性能水凝胶指明了新方向。
