Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L.Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, India.
Shobhaben Pratapbhai Patel School of Pharmacy & Technology Management, SVKMs NMIMS, V.L.Mehta Road, Vile Parle (W), Mumbai, Maharashtra 400056, India.
Drug Discov Today. 2022 Dec;27(12):103371. doi: 10.1016/j.drudis.2022.103371. Epub 2022 Sep 26.
Biotechnology-based therapeutics include a wide range of products, such as recombinant hormones, stem cells, therapeutic enzymes, monoclonal antibodies, genes, vaccines, among others. The administration of these macromolecules has been studied via various routes. The nasal route is one of the promising routes of administration for biotechnology products owing to its easy delivery, the rich vascularity of the nasal mucosa, high absorption and targeted action. Several preclinical studies have been reported for nasal delivery of these products and many are at the clinical stage. This review focuses on biotechnology-based therapeutics administered via the intranasal route for treating various diseases.
基于生物技术的治疗药物包括多种产品，如重组激素、干细胞、治疗性酶、单克隆抗体、基因、疫苗等。这些大分子的给药途径已经通过各种途径进行了研究。由于鼻腔给药具有给药方便、鼻腔黏膜血管丰富、吸收高、靶向作用强等优点，因此成为生物技术产品有前途的给药途径之一。已经有报道称，这些产品可以通过鼻腔给药进行临床前研究，其中许多已经进入临床阶段。本综述重点介绍了通过鼻内途径给药的生物技术治疗药物，用于治疗各种疾病。
