Qinrong Huang, Yuxia Chen, Ling Liu, Huayu Luo, Lei Xu, Xiaoli Li, Nong Xiao
Department of Rehabilitation Children's Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing, People's Republic of China.
Department of Rehabilitation Children's Hospital of Fudan University, Shanghai, People's Republic of China.
Dev Med Child Neurol. 2023 Apr;65(4):563-570. doi: 10.1111/dmcn.15418. Epub 2022 Sep 29.
To explore the clinical characteristics and prognostic predictors of Guillain-Barré syndrome (GBS) in Chinese paediatric patients.
The clinical features of children with GBS hospitalized in the Children's Hospital of Chongqing Medical University were summarized retrospectively. The correlation between the Erasmus GBS Outcome Score (EGOS)/modified Erasmus GBS Outcome Score (mEGOS), GBS disability score (GDS)/modified Rankin Scale (MRS), Erasmus GBS Respiratory Insufficiency Score (EGRIS), and mechanical ventilation were evaluated.
One hundred forty-two patients (86 males, 56 females; median 62.50 months [interquartile range 41.00-97.50]) with classic GBS were enrolled in the study. In the present GBS cohort, 134 (94.37%) patients could walk independently (GDS ≤2) and 121 (85.21%) could manage without assistance (MRS ≤2) at 6 months. Eighteen (12.68%) patients with GBS required mechanical ventilation. The performance of mEGOS on admission, mEGOS on day 7, and EGOS-predicted GDS outcome at 4 weeks, 3 months, and 6 months in the paediatric patients with GBS admitted within 2 weeks of disease onset and that of the MRS outcome were evaluated. The EGRIS in individuals who required mechanical ventilation was significantly higher than in patients without mechanical ventilation (median = 6 vs median = 3, p < 0.001).
In Chinese paediatric patients with GBS who were admitted 2 weeks after disease onset, the mEGOS and EGOS are validated indicators for the prediction of clinical outcomes 6 months after onset. EGRIS is helpful in predicting the implementation of mechanical ventilation in the acute phase.
The Erasmus Guillain-Barré syndrome (GBS) Outcome Score (EGOS) and modified EGOS are reliable prognostic predictors in paediatric patients with GBS. The Erasmus GBS Respiratory Insufficiency Score (EGRIS) is an effective predictor of mechanical ventilation in paediatric patients with GBS. An EGRIS of ≥5 indicates a high risk of mechanical ventilation in the acute phase.
探讨中国儿童吉兰 - 巴雷综合征（GBS）的临床特征及预后预测因素。
回顾性总结重庆医科大学附属儿童医院收治的GBS患儿的临床特征。评估伊拉斯谟GBS结局评分（EGOS）/改良伊拉斯谟GBS结局评分（mEGOS）、GBS残疾评分（GDS）/改良Rankin量表（MRS）、伊拉斯谟GBS呼吸功能不全评分（EGRIS）与机械通气之间的相关性。
142例（男86例，女56例；中位年龄62.50个月[四分位间距41.00 - 97.50]）经典GBS患儿纳入研究。在当前GBS队列中，134例（94.37%）患儿在6个月时可独立行走（GDS≤2），121例（85.21%）无需帮助（MRS≤2）。18例（12.68%）GBS患儿需要机械通气。对发病2周内入院的GBS患儿，评估其入院时mEGOS、第7天mEGOS以及4周、3个月和6个月时EGOS预测的GDS结局与MRS结局的情况。需要机械通气的患儿EGRIS显著高于未进行机械通气的患儿（中位数 = 6 vs中位数 = 3，p < 0.001）。
对于发病2周后入院的中国GBS患儿，mEGOS和EGOS是发病6个月后临床结局的有效预测指标。EGRIS有助于预测急性期机械通气的实施情况。
伊拉斯谟吉兰 - 巴雷综合征（GBS）结局评分（EGOS）和改良EGOS是GBS患儿可靠的预后预测指标。伊拉斯谟GBS呼吸功能不全评分（EGRIS）是GBS患儿机械通气的有效预测指标。EGRIS≥5表明急性期机械通气风险高。
