Department of Anatomy and Neurobiology, Research Center for Sectional and Imaging Anatomy, Shandong Provincial Key Laboratory of Mental Disorder, Shandong Key Laboratory of Digital Human and Clinical Anatomy, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, 250012, Shandong, China.
Institute of Brain and Brain-Inspired Science, Shandong University, Jinan, 250012, Shandong, China.
Commun Biol. 2022 Sep 29;5(1):1031. doi: 10.1038/s42003-022-04003-6.
Inherent hemispheric asymmetry is important for cognition, language and other functions. Describing normal brain and asymmetry development during early development will improve our understanding of how different hemispheres prioritize specific functions, which is currently unknown. Here, we analysed developmental changes in and asymmetry of the proteome in the bilateral frontal lobes of three foetal specimens in the late first trimester of pregnancy. We found that during this period, the difference in expression between gestational weeks (GWs) increased, and the difference in asymmetric expression decreased. Changes in the patterns of protein expression differed in the bilateral frontal lobes. Our results show that brain asymmetry can be observed in early development. These findings can guide researchers in further investigations of the mechanisms of brain asymmetry. We propose that both sides of the brain should be analysed separately in future multiomics and human brain mapping studies.
大脑半球固有的不对称性对认知、语言和其他功能很重要。描述早期发育过程中正常大脑和不对称性的发展将有助于我们了解不同大脑半球如何优先考虑特定功能，而这目前尚不清楚。在这里，我们分析了三个妊娠第一期末胎儿样本双侧额叶蛋白质组的发育变化和不对称性。我们发现，在此期间，妊娠周（GW）之间的表达差异增加，而不对称表达的差异减少。双侧额叶的蛋白质表达模式变化不同。我们的研究结果表明，大脑的不对称性可以在早期发育中观察到。这些发现可以指导研究人员进一步研究大脑不对称的机制。我们建议，在未来的多组学和人类大脑图谱研究中，应该分别对大脑两侧进行分析。
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