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[利用车前草汁液对小鼠小肠黏膜中5-氟尿嘧啶毒性作用的稀释]

[Dilution of the toxic action of 5-fluorouracil on the mucosa of the small intestine in mice using the sap of plantain].

作者信息

Borovskaia T G, Udintsev S N, Zueva E P, Fomina T I, Neĭshtadt E L

出版信息

Vopr Onkol. 1987;33(7):60-4.

PMID:3617613
Abstract

The study was concerned with an attempt at reducing the acute toxic effect of 5-fluorouracil (5-FU) on gut mucosa in mice with Ehrlich ascites tumors. An official preparation of plantain sap was shown to ward off this effect and to contribute to the normalising of certain parameters of epithelial cells. The DNA level of tumor cells showed a more drastic decline after combined treatment with 5-FU and the preparation than after the cytostatic drug alone.

摘要

该研究旨在尝试减轻5-氟尿嘧啶(5-FU)对患有艾氏腹水瘤的小鼠肠道黏膜的急性毒性作用。结果表明,一种官方制备的车前草汁液能够抵御这种作用,并有助于使上皮细胞的某些参数恢复正常。与单独使用细胞抑制药物相比,5-FU与该制剂联合治疗后肿瘤细胞的DNA水平下降更为显著。

相似文献

1
[Dilution of the toxic action of 5-fluorouracil on the mucosa of the small intestine in mice using the sap of plantain].[利用车前草汁液对小鼠小肠黏膜中5-氟尿嘧啶毒性作用的稀释]
Vopr Onkol. 1987;33(7):60-4.
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Kinetic alterations induced by 5-fluorouracil in bone marrow, intestinal mucosa, and tumor.5-氟尿嘧啶对骨髓、肠黏膜及肿瘤所诱导的动力学改变。
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[Enhancement of the selectivity of the action of the cytostatics cyclophosphane and 5-fluorouracil by using an extract of the Baikal skullcap in an experiment].[在实验中使用贝加尔黄芩提取物提高细胞抑制剂环磷酰胺和5-氟尿嘧啶作用的选择性]
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Plant Polysaccharides Attenuate Fluorouracil Toxicity for the Small Intestinal Epithelium.
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Histological examination of combined effects of chemotherapeutical agents and differently fractionated irradiations in transplanted solid Ehrlich carcinoma of mice. III. Observations after vincristine treatment.化疗药物与不同分割照射联合作用对小鼠移植性实体艾氏癌的组织学检查。III. 长春新碱治疗后的观察结果
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Antitumor activity and antioxidant role of Bauhinia racemosa against Ehrlich ascites carcinoma in Swiss albino mice [corrected].毛羊蹄甲对瑞士白化小鼠艾氏腹水癌的抗肿瘤活性及抗氧化作用[校正后]
Acta Pharmacol Sin. 2004 Aug;25(8):1070-6.
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[Biochemical differences in the tumor cells of 5-fluorouracil-sensitive and -resistant strains of Ehrlich ascitic carcinoma].[艾氏腹水癌5-氟尿嘧啶敏感和耐药菌株肿瘤细胞的生化差异]
Biull Eksp Biol Med. 1983 Feb;95(2):72-4.