Khristov V, Popova D, Kolebinov N
Vutr Boles. 1987;26(3):64-8.
The 24-h urine excretion and renal clearance of albumin, alpha I-acid glycoprotein, transferrin, IgG, IgA and haptoglobin were studied in 30 albustix-negative diabetics with no clinical data for diabetic nephropathy aiming at the precise characterization of proteinuria in patients with diabetes mellitus. The diabetic patients were divided into two groups - 15 patients with newly diagnosed diabetes and 15 - with a longer duration of diabetes. Thirteen healthy subjects, at the same mean age, served as a control group. The results reveal increase of the clearances and 24-h excretion of the proteins studied in the patients with diabetes mellitus, in those with a short duration of the disease including, with authentic difference for albumin, transferrin, IgG and haptoglobin among the patients with a longer duration of the disease and the healthy controls and authentic difference for albumin between those with the newly diagnosed diabetes and the healthy control. The possible prognostic significance of the indices studied is discussed as well as their importance for the early diagnosis of diabetic nephropathy.
对30例尿糖试纸检测为阴性且无糖尿病肾病临床数据的糖尿病患者进行了研究，测定其24小时尿白蛋白、α1 - 酸性糖蛋白、转铁蛋白、IgG、IgA和触珠蛋白的排泄量及肾清除率，旨在精确表征糖尿病患者的蛋白尿情况。糖尿病患者被分为两组——15例新诊断糖尿病患者和15例糖尿病病程较长的患者。13名年龄均值相同的健康受试者作为对照组。结果显示，糖尿病患者，尤其是病程较短的患者，所研究蛋白质的清除率和24小时排泄量均增加，病程较长的患者与健康对照组相比，白蛋白、转铁蛋白、IgG和触珠蛋白存在显著差异，新诊断糖尿病患者与健康对照组相比，白蛋白也存在显著差异。文中还讨论了所研究指标可能的预后意义及其对糖尿病肾病早期诊断的重要性。
