Barczyk J, Puchalski Z B, Trochimowicz L
Z Exp Chir Transplant Kunstliche Organe. 1987;20(3):144-50.
The influence of hydrocortisone on the behaviour of the concentration of dopamine (DA), noradrenaline (NA), and homovanillic acid (HVA) were estimated in liver homogenates in the course of the experimental endotoxic shock. The concentration of DA and NA decrease in untreated animals in the 2nd and 4th hour in order to increase significantly in the 6th hour. The concentration of the HVA also increased in the 6th hour after a transitory significant decrease. - The values in the treated animals were in case of DA increased in the 2nd and 4th hour and decreased significantly in the 6th hour. In case of NA they decreased in the 2nd and 4th and increased significantly in the 6th hour and the values for HVA increased significantly in the whole time. The favourable effect of the hydrocortisone in the treated group can be traced back to the increased DA concentration, the decreased NA concentration and the better utilization of the DA by the tissue. This increased HVA could be evidence for them.
在实验性内毒素休克过程中，评估了氢化可的松对肝匀浆中多巴胺（DA）、去甲肾上腺素（NA）和高香草酸（HVA）浓度变化的影响。未处理动物中，DA和NA的浓度在第2小时和第4小时下降，而在第6小时显著升高。HVA的浓度在短暂显著下降后，也在第6小时升高。——处理组动物中，DA的浓度在第2小时和第4小时升高，在第6小时显著下降。NA的浓度在第2小时和第4小时下降，在第6小时显著升高，而HVA的浓度在整个过程中显著升高。处理组中氢化可的松的有利作用可归因于DA浓度的升高、NA浓度的降低以及组织对DA更好的利用。升高的HVA可能是其证据。
