Bahmer F A, Bader M
Z Hautkr. 1987 May 1;62(9):691-5.
We report on 52 dermatologic patients suffering from chronic alcoholism. The skin changes observed mainly consisted of erythrosis interfollicularis colli, icterus of the sclerae, teleangiectatic reddening of the face, and diminished secondary hair. In 29 out of 44 sera investigated, we found elevation of the gamma-glutamyl transferase. In 17 patients, serum samples were analyzed for zinc. In 16 cases, the zinc levels were slightly decreased but still within the normal range, i.e. below 100 micrograms/dl. The biotin levels in the 48 serum samples examined varied very much. In 6 patients, however, we found definitely lowered values. Our results support the view that routine investigation of serum zinc and biotin levels might be valuable in patients suffering from chronic alcoholism associated with cutaneous changes. If lowered values are found, a substitution therapy might be of benefit at least in some patients.
我们报告了52例患有慢性酒精中毒的皮肤科患者。观察到的皮肤变化主要包括颈部毛囊间红斑、巩膜黄疸、面部毛细血管扩张性发红以及继发性毛发减少。在44份被检测的血清中，有29份γ-谷氨酰转移酶升高。对17例患者的血清样本进行了锌含量分析。在16例中，锌水平略有下降，但仍在正常范围内，即低于100微克/分升。所检测的48份血清样本中的生物素水平差异很大。然而，在6例患者中，我们发现其值明显降低。我们的结果支持这样一种观点，即对患有与皮肤变化相关的慢性酒精中毒患者进行血清锌和生物素水平的常规检测可能是有价值的。如果发现值降低，替代疗法至少对一些患者可能有益。
