Rita Levi-Montalcini Department of Neuroscience, University of Turin, Turin, Italy.
PLoS Biol. 2022 Sep 30;20(9):e3001789. doi: 10.1371/journal.pbio.3001789. eCollection 2022 Sep.
Long-term memory formation involves the reorganization of brain circuits, termed system consolidation. Whether and how a prior fear experience influences system consolidation of new memories is poorly understood. In rats, we found that prior auditory fear learning allows the secondary auditory cortex to immediately encode new auditory memories, with these new memories purely requiring the activation of cellular mechanisms of synaptic consolidation within secondary auditory cortex. Similar results were obtained in the anterior cingulate cortex for contextual fear memories. Moreover, prior learning enabled connections from these cortices to the basolateral amygdala (BLA) to support recent memory retention. We propose that the reorganization of circuits that characterizes system consolidation occurs only in the first instance that an event is learned, subsequently allowing the immediate assimilation of new analogous events in final storage sites.
长期记忆的形成涉及到脑回路的重组，被称为系统巩固。先前的恐惧经验是否以及如何影响新记忆的系统巩固还知之甚少。在大鼠中，我们发现先前的听觉恐惧学习使次级听觉皮层能够立即编码新的听觉记忆，这些新的记忆仅需要激活次级听觉皮层中的突触巩固的细胞机制。在前扣带皮层中也获得了类似的结果，用于情境恐惧记忆。此外，先前的学习使来自这些皮层的连接能够支持基底外侧杏仁核（BLA）来支持最近的记忆保留。我们提出，系统巩固的特征是电路的重组仅在事件首次被学习时发生，随后允许新的类似事件立即在最终存储位置中同化。
