Departments of Neurology.
Psychiatry, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, Japan.
Clin Nucl Med. 2022 Dec 1;47(12):1066-1068. doi: 10.1097/RLU.0000000000004425. Epub 2022 Sep 30.
The Alzheimer disease (AD) brain is characterized microscopically by the presence of extracellular amyloid plaques and intraneuronal neurofibrillary tangles consisting of phosphorylated tau aggregations. 18 F-THK5351 is a first-generation PET tau tracer that also binds to monoamine oxidase B, which represents astrogliosis, and is useful to evaluate some non-AD neurodegenerative disorders. We examined the utility of 18 F-THK5351 in preclinical AD using 3-dimensional stereotactic surface projection images optimized for its pathological accumulation by comparison with a normal dataset. By using this 18 F-THK5351 3-dimensional stereotactic surface projection procedure, which can evaluate phosphorylated tau and neuroinflammation, we could diagnose preclinical AD effectively.
阿尔茨海默病（AD）的大脑在显微镜下的特征是存在细胞外淀粉样斑块和由磷酸化 tau 聚集组成的神经元内神经原纤维缠结。 18 F-THK5351 是第一代 PET tau 示踪剂，也与代表星形胶质细胞增生的单胺氧化酶 B 结合，可用于评估某些非 AD 神经退行性疾病。我们通过与正常数据集进行比较，使用针对其病理积累进行了优化的 3 维立体定向表面投影图像来检查 18 F-THK5351 在临床前 AD 中的应用。通过使用这种可以评估磷酸化 tau 和神经炎症的 18 F-THK5351 3 维立体定向表面投影程序，我们可以有效地诊断临床前 AD。
