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[用甲基亚硝基脲诱导脑肿瘤。两种大鼠品系的比较研究]

[Induction of brain tumors with methylnitrosourea. Comparative study of 2 strains of rats].

作者信息

Waldbaur H, Hann M, Schmidt H

出版信息

Zentralbl Neurochir. 1987;48(1):56-9.

PMID:3618004
Abstract

For clarifying the question with respect to the different incidence in various animal strains of the formation of cerebral tumours 10 BD II and Wistar rats were given methyl-nitrosourea (a weekly amount of 5 mg per kg of life-weight over a period of 35 weeks). After an average of 398 and 367 days half the number of animals in each group showed cerebral tumours. These primarily seem to be isomorphous gliomas which then show an increase in malignity.

摘要

为了阐明不同动物品系中脑肿瘤形成的发生率差异问题,对10只BD II大鼠和10只Wistar大鼠给予甲基亚硝基脲(在35周内每周每千克体重给予5毫克)。平均398天和367天后,每组半数动物出现脑肿瘤。这些肿瘤最初似乎是同形胶质瘤,随后恶性程度增加。

相似文献

1
[Induction of brain tumors with methylnitrosourea. Comparative study of 2 strains of rats].[用甲基亚硝基脲诱导脑肿瘤。两种大鼠品系的比较研究]
Zentralbl Neurochir. 1987;48(1):56-9.
2
In vitro transformation of fetal brain cells from CDF rats exposed in utero to N-ethyl-N-nitrosourea: morphologic and immunologic studies.子宫内暴露于N-乙基-N-亚硝基脲的CDF大鼠胎脑细胞的体外转化:形态学和免疫学研究
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IARC Sci Publ. 1989(96):121-9.
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[Brain tumors in the rat induced by methylnitrosourea (induction, transplantation, monolayer cultivation)].[甲基亚硝基脲诱导大鼠脑肿瘤(诱导、移植、单层培养)]
Zh Vopr Neirokhir Im N N Burdenko. 1983 Mar-Apr(2):52-9.
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The induction of tumors of the nervous system with intravenous methylnitrosourea.静脉注射甲基亚硝基脲诱导神经系统肿瘤
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The influence of hypoxia on the induction of experimental brain tumors in rats.缺氧对大鼠实验性脑肿瘤诱导的影响。
Neuropatol Pol. 1982;20(1-2):151-4.
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Estrous cycle modification of rat mammary tumor induction by a single dose of N-methyl-N-nitrosourea.单次给予N-甲基-N-亚硝基脲诱导大鼠乳腺肿瘤过程中发情周期的改变
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Brain tumour induction by methylnitrosourea. Influence of the circadian rhythm on tumour induction by nitrosourea.甲基亚硝基脲诱导脑肿瘤。昼夜节律对亚硝基脲诱导肿瘤的影响。
Neuropatol Pol. 1977 Jan-Mar;15(1):137-44.
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