[用甲基亚硝基脲诱导脑肿瘤。两种大鼠品系的比较研究]
[Induction of brain tumors with methylnitrosourea. Comparative study of 2 strains of rats].
作者信息
Waldbaur H, Hann M, Schmidt H
出版信息
Zentralbl Neurochir. 1987;48(1):56-9.
PMID:3618004
Abstract
For clarifying the question with respect to the different incidence in various animal strains of the formation of cerebral tumours 10 BD II and Wistar rats were given methyl-nitrosourea (a weekly amount of 5 mg per kg of life-weight over a period of 35 weeks). After an average of 398 and 367 days half the number of animals in each group showed cerebral tumours. These primarily seem to be isomorphous gliomas which then show an increase in malignity.
摘要
为了阐明不同动物品系中脑肿瘤形成的发生率差异问题，对10只BD II大鼠和10只Wistar大鼠给予甲基亚硝基脲（在35周内每周每千克体重给予5毫克）。平均398天和367天后，每组半数动物出现脑肿瘤。这些肿瘤最初似乎是同形胶质瘤，随后恶性程度增加。
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