难怪：纳米颗粒将羟氯喹递送给活化的中性粒细胞。
Small wonder: nanoparticles feed hydroxychloroquine to activated neutrophils.
机构信息
Division of Rheumatology, University of Michigan, Ann Arbor, MI, USA.
出版信息
Nat Rev Rheumatol. 2022 Dec;18(12):675-676. doi: 10.1038/s41584-022-00854-9.
Abstract
Although neutrophils are vital components of the innate immune system, they can also contribute to the inflammation and autoantibody formation that characterize a number of rheumatic diseases. The ability to specifically target neutrophils, and in particular activated neutrophils, could enable the direct delivery of drugs for therapeutic modulation of neutrophil activity.
摘要
虽然中性粒细胞是先天免疫系统的重要组成部分，但它们也可能导致许多风湿性疾病的炎症和自身抗体形成。特异性靶向中性粒细胞，特别是激活的中性粒细胞的能力，可以实现药物的直接递送，从而治疗性调节中性粒细胞的活性。
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