氯喹和羟氯喹对趋化性三肽刺激的人中性粒细胞多形核白细胞超氧化物生成的抑制机制研究。
Studies on the mechanism of inhibition of chemotactic tripeptide stimulated human neutrophil polymorphonuclear leucocyte superoxide production by chloroquine and hydroxychloroquine.
作者信息
Hurst N P, French J K, Gorjatschko L, Betts W H
机构信息
Queen Elizabeth Hospital Rheumatology Unit, Woodville, South Australia.
出版信息
Ann Rheum Dis. 1987 Oct;46(10):750-6. doi: 10.1136/ard.46.10.750.
Abstract
The effect of chloroquine and hydroxychloroquine on neutrophil superoxide release stimulated by the chemotactic tripeptide N-formyl-methionyl-leucyl-phenylalanine (FMLP) was examined. Both drugs caused time and dose dependent inhibition of superoxide release but had no effect on equilibrium binding of [3H]FMLP to its receptor. Preliminary experiments suggest that these drugs may exert their inhibitory effect on superoxide release by inhibiting the FMLP stimulated hydrolysis of phosphoinositides.
摘要
研究了氯喹和羟氯喹对趋化性三肽N-甲酰甲硫氨酰-亮氨酰-苯丙氨酸（FMLP）刺激的中性粒细胞超氧化物释放的影响。两种药物均引起超氧化物释放的时间和剂量依赖性抑制，但对[3H]FMLP与其受体的平衡结合无影响。初步实验表明，这些药物可能通过抑制FMLP刺激的磷酸肌醇水解对超氧化物释放发挥抑制作用。
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