Karma P, Sipilä M, Koskela M, Peltola H
Acta Otolaryngol. 1987 May-Jun;103(5-6):395-9.
Serum C-reactive protein (CRP) levels were studied in 79 children with acute otitis media (AOM), aged from 4 months to 5 years. The CRP was less than 10 mg/l in 27 children, greater than or equal to 20 mg/l in 34, and greater than or equal to 40 mg/l in 17 children, 25 of the 41 attacks caused by S. pneumoniae or H. influenzae showed a CRP of greater than or equal to 20 mg/l and 15 CRP greater than or equal to 40 mg/l, in 38 cases without major otitis pathogens, the respective figures were 9 (p less than 0.01) and 2 (p less than 0.001). Although statistically significant correlations between otitis-related clinical parameters and CRP levels were rare, there was a tendency toward higher CRP values among those with a more severe clinical picture. All five attacks with CRP greater than or equal to 100 mg/l were bilateral, caused by major pathogens, and preceded by a respiratory infection. They also tended to have high fever and a large amount of fluid in myringotomy. However, even in these the general course of AOM and other morbidity was not different from the others.
对79名年龄在4个月至5岁之间的急性中耳炎（AOM）患儿的血清C反应蛋白（CRP）水平进行了研究。27名儿童的CRP低于10mg/L，34名儿童的CRP大于或等于20mg/L，17名儿童的CRP大于或等于40mg/L，由肺炎链球菌或流感嗜血杆菌引起的41次发作中，有25次的CRP大于或等于20mg/L，15次的CRP大于或等于40mg/L；在38例无主要中耳炎病原体的病例中，相应数字分别为9例（p<0.01）和2例（p<0.001）。虽然中耳炎相关临床参数与CRP水平之间的统计学显著相关性很少见，但在临床表现较严重的患儿中，CRP值有升高的趋势。所有5次CRP大于或等于100mg/L的发作均为双侧性，由主要病原体引起，且之前有呼吸道感染。他们还往往有高热和鼓膜切开术中大量积液。然而，即使在这些病例中，AOM的总体病程和其他发病率与其他病例并无不同。
