Plastics, micro- and nano-plastics pollution are undoubtedly a severe and crucial ecological threat due to the durability of plastics and their destructive impacts on humans and wildlife. Most scientific investigations have addressed the classification, types, distribution, ingestion, fate, impacts, degradation, and various adverse effect of plastics. Heretofore, scanty reports have addressed implementing strategies for the remediation and mitigation of plastics. Therefore, in this paper, we review the current studies on the degradation of plastics, micro- and nano-plastics aided by microorganisms, and explore the relevant degradation properties and mechanisms. Diverse microorganisms are classified, such as bacteria, fungi, algae, cyanobacteria, wax worms, and enzymes that can decompose various plastics. Furthermore, bio-degradation is influenced by microbial features and environmental parameters; therefore, the ecological factors affecting plastic degradation and the resulting degradation consequences are discussed. In addition, the mechanisms underlying microbial-mediated plastic degradation are carefully studied. Finally, upcoming research directions and prospects for plastics degradation employing microorganisms are addressed. This review covers a comprehensive overview of the microorganism-assisted degradation of plastics, micro- and nano-plastics, and serves as a resource for future research into sustainable plastics pollution management methods.