肠道纤维化和消退中的巨噬细胞。

Macrophages in intestinal fibrosis and regression.

机构信息

Department of Oral Medicine, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; College of Stomatology, Shanghai Jiao Tong University, Shanghai 200011, China; National Center for Stomatology, Shanghai 200011, China; National Clinical Research Center for Oral Diseases, Shanghai 200011, China; Shanghai Key Laboratory of Stomatology, Shanghai 200011, China.

出版信息

Cell Immunol. 2022 Nov;381:104614. doi: 10.1016/j.cellimm.2022.104614. Epub 2022 Sep 24.

DOI:10.1016/j.cellimm.2022.104614

PMID:36182587

Abstract

Intestinal macrophages are heterogenous cell populations with different developmental ontogeny and tissue anatomy. The concerted actions of intestinal macrophage subsets are critical to maintaining tissue homeostasis. However, the dysregulation of macrophages following tissue injury or chronic inflammation could also lead to intestinal fibrosis, with few treatment options in the clinic. In this review, we will characterize the features of intestinal macrophages in light of the latest advances in lineage tracing and single-cell sequencing technology. The roles of macrophages in distinct stages of intestinal fibrosis would be also elaborated. Finally, based on the reciprocal interaction between macrophages and intestinal fibrosis, we will propose the potential macrophage targeting anti-intestinal fibrosis therapies.

摘要

肠道巨噬细胞是具有不同发育起源和组织解剖结构的异质性细胞群体。肠道巨噬细胞亚群的协同作用对于维持组织内稳态至关重要。然而，组织损伤或慢性炎症后巨噬细胞的失调也可能导致肠道纤维化，临床上的治疗选择有限。在这篇综述中，我们将根据谱系追踪和单细胞测序技术的最新进展，描述肠道巨噬细胞的特征。还将阐述巨噬细胞在肠道纤维化不同阶段的作用。最后，基于巨噬细胞和肠道纤维化之间的相互作用，我们将提出潜在的针对巨噬细胞的抗肠道纤维化治疗方法。