Guiot-Goffioul F, Gerard-Vandenhove M A, Troisfontaines B, Breulet M, von Frenckell R, Bobon D
Acta Psychiatr Belg. 1987 Mar-Apr;87(2):230-5.
Rolipram facilitates the postsynaptic neurotransmission of NA through a completely new mechanism of action, namely, an inhibition of the inactivation of the second messenger (the cyclic AMP) by phosphodiesterase. In the present study, Rolipram is compared to a classical tricyclic antidepressant which facilitates the NA transmission through an inhibition of its presynaptic reuptake: Desipramine. Preliminary results on 12 Rolipram patients vs. 9 Desipramine patients indicate that Rolipram has an antidepressant potency comparable to Desipramine with less anticholinergic and hypotensive side effects. This study also illustrates that a 14-factor AMDP profile gives much more information than a single total score such as the Hamilton score.
咯利普兰通过一种全新的作用机制促进去甲肾上腺素（NA）的突触后神经传递，即抑制磷酸二酯酶对第二信使（环磷酸腺苷）的失活作用。在本研究中，将咯利普兰与一种经典的三环类抗抑郁药——通过抑制NA的突触前再摄取来促进NA传递的地昔帕明进行比较。12例服用咯利普兰的患者与9例服用地昔帕明的患者的初步结果表明，咯利普兰的抗抑郁效力与地昔帕明相当，且抗胆碱能和降压副作用较少。这项研究还表明，14项AMDP量表提供的信息比诸如汉密尔顿量表这样的单一总分要多得多。
