Hospital Pharmacy Department, Hospital Infanta Elena, Huelva. Spain..
Fundación Andaluza Beturia para la Investigación en Salud, Huelva. Spain. Department of Social, Developmental and Educational Psychology, Universidad de Huelva, Huelva. Spain..
Farm Hosp. 2022 Mar 4;46(3):152-156.
To analyze the local and systemic reactions that appeared after the first and second dose of the BNT162b2 vaccine against COVID‑19 (Pfizer- BioNTech) in a sample of workers from a tertiary hospital, and to identify the factors related to greater vaccine reactogenicity.
A self-administered questionnaire was used to interview 291 workers from a tertiary hospital who received the BNT162b2 vaccine against COVID-19 between January and March 2021. The questionnaire included questions about the sociodemographic variables of the participants, previous COVID-19 infection, and local and systemic reactions after the first and second dose of the vaccine.
The most common adverse reaction was soreness at the injection site, which was reported more frequently after the first dose of the vaccine. The systemic reactions evaluated were reported more frequently after the second dose of the vaccine. Women, younger adults, and subjects with a prior COVID-19 infection reported increased reactogenicity. Furthermore, high reactogenicity after the first dose was found to be related to a higher number of adverse reactions after the second dose of the vaccine.
The distribution of reactogenicity in the present study is consistent with the data reported in previous studies on the BNT162b2 vaccine, especially in terms of its association with the participants' characteristics. These findings could facilitate the identification of people at a higher risk of developing high reactogenicity to the vaccine, thereby making it possible to anticipate the appearance of adverse reactions and plan for their treatment.
分析在一家三级医院的工作人员样本中，首次和第二次接种 BNT162b2 疫苗（辉瑞-生物科技）后出现的局部和全身反应，并确定与更大疫苗反应原性相关的因素。
采用自填式问卷对 2021 年 1 月至 3 月期间接种 BNT162b2 疫苗的 291 名三级医院工作人员进行访谈。问卷包括参与者的社会人口统计学变量、既往 COVID-19 感染以及首次和第二次接种疫苗后的局部和全身反应的问题。
最常见的不良反应是注射部位疼痛，该反应在接种第一剂疫苗后更为常见。评估的全身反应在接种第二剂疫苗后更为常见。女性、年轻成年人和既往 COVID-19 感染的受试者报告的反应原性增加。此外，第一剂疫苗高反应原性与第二剂疫苗不良反应增加相关。
本研究中的反应原性分布与之前关于 BNT162b2 疫苗的研究数据一致，尤其是与参与者特征的关联。这些发现有助于识别对疫苗反应原性较高的人群，从而预测不良反应的出现并为其治疗做好计划。
