Psychology and Neuroscience of Cognition Research Unit, University of Liège, Belgium; Fund for Scientific Research FNRS, 1000, Brussels, Belgium.
Psychology and Neuroscience of Cognition Research Unit, University of Liège, Belgium.
Neuropsychologia. 2022 Nov 5;176:108377. doi: 10.1016/j.neuropsychologia.2022.108377. Epub 2022 Sep 30.
There remain major doubts about the nature and domain specificity of inhibitory control processes, both within and between cognitive domains. This study examined inhibitory processes within the language domain, by contrasting semantic versus phonological inhibitory control. In an fMRI experiment, elderly participants performed phonological and semantic inhibitory control tasks involving resistance to highly or weakly interfering stimuli. In the semantic domain, inhibitory control effects, contrasting high vs. low interference control levels, were observed at univariate and multivariate levels in all fronto-parieto-temporal region-of-interests. In the phonological domain, inhibitory control effects were observed only at multivariate levels, and were restricted to the pars triangularis of the bilateral inferior frontal gyrus and to the left middle temporal gyrus. Critically, no reliable multivariate cross-domain prediction of neural patterns associated with inhibitory control was observed. This study supports a functional dissociation of the neural substrates associated with inhibitory control for phonological vs. semantic domains.
内抑制控制过程的性质和领域特异性仍然存在很大的疑问,无论是在认知领域内部还是之间。本研究通过对比语义与语音抑制控制,考察了语言领域内的抑制过程。在 fMRI 实验中,老年参与者完成了语音和语义抑制控制任务,涉及对高度或低度干扰刺激的抵抗。在语义领域中,在单变量和多变量水平上,在所有额顶颞叶感兴趣区中均观察到了高干扰与低干扰控制水平之间的抑制控制效应。在语音领域中,仅在多变量水平上观察到抑制控制效应,并且仅限于双侧额下回的三角部和左颞中回。关键的是,没有观察到与抑制控制相关的神经模式的跨领域多变量可靠预测。本研究支持与语音和语义领域相关的抑制控制的神经基质的功能分离。