Laboratorio de Fisio-Patología Ovárica, Centro de Estudios Farmacológicos y Botánicos, Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
Laboratorio de Fisio-Patología Ovárica, Centro de Estudios Farmacológicos y Botánicos, Consejo Nacional de Investigaciones Científicas y Técnicas, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina.
J Steroid Biochem Mol Biol. 2023 Jan;225:106195. doi: 10.1016/j.jsbmb.2022.106195. Epub 2022 Sep 29.
Polycystic ovary syndrome (PCOS) is one of the main endocrine and reproductive disorders affecting women in their reproductive age. The syndrome is considered a multifactorial pathology. Therefore, genetic susceptibility and environmental factors contribute to PCOS development and phenotypic manifestation. Ethnicity and socioeconomic factors influence the development of PCOS and could affect the possibility of its diagnosis. Latin America is a unique case of study because of the heterogeneity within the region, complex socioeconomic status, and the mixed ancestry found in these populations. Up-to-date, most studies have focused on developed countries' populations, and there is a lack of evidence regarding Latin-American countries. We propose to review the state of the art of PCOS knowledge regarding Latin American populations, including the metabolic and reproductive aspects of the syndrome and the different influencing factors, and suggest future directions to deepen the study of PCOS.
多囊卵巢综合征（PCOS）是影响育龄妇女的主要内分泌和生殖系统疾病之一。该综合征被认为是一种多因素病理。因此，遗传易感性和环境因素促成了 PCOS 的发展和表型表现。种族和社会经济因素影响 PCOS 的发展，并可能影响其诊断的可能性。拉丁美洲是一个独特的研究案例，因为该地区存在异质性、复杂的社会经济地位以及这些人群中发现的混合血统。迄今为止，大多数研究都集中在发达国家的人群，而关于拉丁美洲国家的证据不足。我们建议综述有关拉丁美洲人群的 PCOS 知识现状，包括该综合征的代谢和生殖方面以及不同的影响因素，并提出进一步研究 PCOS 的未来方向。
