Takahashi Y, Horie M, Isogai K, Takeuchi T, Shinoda I, Kuriyama M, Ban Y
Hinyokika Kiyo. 1987 Mar;33(3):396-9.
A squamous cell carcinoma-related antigen (SCC-Ag), which has been recognized as a tumor marker of cervical cancer of the uterine, was detected in the serum with a radioimmunoassay and its clinical usefulness in penile cancer was evaluated. Seven serum samples of penile cancer, one of Paget's disease and two of condyloma acuminatum were analyzed for the SCC-Ag level. The mean +/- standard deviation of serum SCC-Ag level and positive rate (greater than 2.0 ng/ml) were 1.6 +/- 1.75 ng/ml and 14%. Neither pathological staging nor cell grading of penile cancer showed any relation to the serum SCC-Ag level. When the tumor of the penis has been recognized and a cut-off value of 1.0 ng/ml used, the positive rate of penile cancer was 71.4% and false positive rate of other benign penile tumors was 0%. Serum SCC-Ag values were changed parallel in to the clinical course in three patients. These results suggest that the detection of the serum SCC-Ag value may be of use for detection of penile cancer and monitoring of these patients.
鳞状细胞癌相关抗原（SCC-Ag）已被公认为子宫颈癌的肿瘤标志物，采用放射免疫分析法检测血清中的SCC-Ag，并评估其在阴茎癌中的临床应用价值。分析了7份阴茎癌血清样本、1份佩吉特病血清样本和2份尖锐湿疣血清样本中的SCC-Ag水平。血清SCC-Ag水平的平均值±标准差为1.6±1.75 ng/ml，阳性率（大于2.0 ng/ml）为14%。阴茎癌的病理分期和细胞分级均与血清SCC-Ag水平无任何关系。当阴茎肿瘤被确诊且采用1.0 ng/ml的临界值时，阴茎癌的阳性率为71.4%，其他良性阴茎肿瘤的假阳性率为0%。3例患者的血清SCC-Ag值随临床病程平行变化。这些结果表明，检测血清SCC-Ag值可能有助于阴茎癌的检测及对这些患者的监测。
