印度极早产儿和中度早产儿的短期神经发育和生长结局。

Short-term neurodevelopment and growth outcomes of very and moderate preterm Indian infants.

机构信息

Department of Pediatrics, All India Institute of Medical Sciences (AIIMS), New Delhi, India.

Department of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research, Puducherry, India.

出版信息

J Perinatol. 2022 Nov;42(11):1489-1495. doi: 10.1038/s41372-022-01519-x. Epub 2022 Oct 2.

DOI:10.1038/s41372-022-01519-x

PMID:36184641

Abstract

OBJECTIVE

To study the growth and neurodevelopmental outcome of very and moderate preterm infants (VMPT) compared to term appropriate-for-age (term AGA) infants at 18-months corrected age.

METHODS

This prospective cohort study enrolled consecutively born 212 VMPT infants and 250 term AGA controls delivered during study period.

OUTCOME MEASURES

Major neurodevelopmental impairment (NDI) defined as any one of cerebral palsy, motor (MoDQ) or mental developmental quotient (MoDQ) <70 on Developmental Assessment Scale for Indian infants, visual or hearing impairment, or epilepsy, and growth outcomes.

RESULTS

Among 195 VMPT and 240 term AGA infants who completed follow-up, the frequency of major NDI was 12.8% and 2.5% respectively (RR 5.1; 95% CI [2.13-12.19]). Major NDI was higher among infants <28 weeks gestation (39%) and birthweight <1000 grams (27%). A quarter of VMPT infants exhibited wasting and 18% stunting than 7% each among controls.

CONCLUSION

VMPT infants had a higher frequency of major NDI and growth failure at 18-months.

摘要

目的

研究极早产儿和中度早产儿（VMPT）与足月适宜年龄（足月 AGA）婴儿在 18 个月校正年龄时的生长和神经发育结局。

方法

这项前瞻性队列研究连续纳入了在研究期间分娩的 212 名 VMPT 婴儿和 250 名足月 AGA 对照婴儿。

结局测量

主要神经发育障碍（NDI）定义为任何一种脑瘫、运动（MoDQ）或精神发育商（MoDQ）<70 的发育评估量表对印度婴儿、视力或听力障碍，或癫痫发作，以及生长结局。

结果

在完成随访的 195 名 VMPT 和 240 名足月 AGA 婴儿中，主要 NDI 的发生率分别为 12.8%和 2.5%（RR 5.1；95%CI[2.13-12.19]）。胎龄<28 周和出生体重<1000 克的婴儿中，主要 NDI 的发生率较高（分别为 39%和 27%）。四分之一的 VMPT 婴儿出现消瘦，18%的婴儿出现发育迟缓，而对照组中分别为 7%。