Zhang Xingyu, Zhu Gangcai, Tang Bin, Huang Huimei, Chen Changhan, Zheng Siyuan, Pu Yuting, Xu Yimin, Wang Gang, Huang Donghai, Liu Yong, Zhang Xin
Department of Otolaryngology-Head and Neck Surgery, Xiangya Hospital, Central South University, Changsha, China.
Department of Otolaryngology-Head and Neck Surgery, The Second Xiangya Hospital, Central South University, Changsha, China.
Gland Surg. 2021 Apr;10(4):1325-1338. doi: 10.21037/gs-20-847.
Primary squamous cell carcinoma of the thyroid (PSCCTh) is a sporadic malignancy arising from the thyroid gland. The factors that affect treatment and survival in patients with PSCCTh remain unclear. Our study aims to characterize PSCCTh and establish a prognosis prediction model for patients with PSCCTh.
Clinical data and follow-up information for 277 patients from 1973 to 2016 were collected from the Surveillance, Epidemiology, and End Results Program (SEER) 18-registry database (RRID:SCR_003293). Univariate and multivariate Cox proportional hazards analyses and nomogram modeling of potential prognostic factors were conducted.
Among the collected patient cases, 57% were female and 43% were male. The median survival of all cases was 6 months; by gender, median survival was 5 and 8 months in the female and male groups, respectively. Univariate and multivariate Cox proportional hazards analyses revealed that age, extent of disease (EOD), T stage, N stage, and treatment were independent prognostic indicators for overall survival (OS) and disease-specific survival (DSS) in patients with PSCCTh. In addition, it was confirmed that the established nomogram model had good consistency and discrimination for PSCCTh prognosis as measured by the concordance index (C-index), area under the receiver operating characteristic (ROC) curve (AUC), and calibration curves.
Our study indicates that age, EOD, T stage, N stage, and treatment may correlate with OS and DSS in patients with PSCCTh. Importantly, our nomogram prediction model, constructed using parameters including age, T stage, N stage, and treatment, may assist physicians in evaluating patients' prognoses and providing precise therapy for PSCCTh.
甲状腺原发性鳞状细胞癌（PSCCTh）是一种起源于甲状腺的散发性恶性肿瘤。影响PSCCTh患者治疗和生存的因素尚不清楚。我们的研究旨在对PSCCTh进行特征描述，并建立PSCCTh患者的预后预测模型。
从监测、流行病学和最终结果计划（SEER）18登记数据库（RRID:SCR_003293）中收集了1973年至2016年277例患者的临床数据和随访信息。对潜在预后因素进行单因素和多因素Cox比例风险分析以及列线图建模。
在收集的患者病例中，57%为女性，43%为男性。所有病例的中位生存期为6个月；按性别划分，女性和男性组的中位生存期分别为5个月和8个月。单因素和多因素Cox比例风险分析显示，年龄、疾病范围（EOD）、T分期、N分期和治疗是PSCCTh患者总生存期（OS）和疾病特异性生存期（DSS）的独立预后指标。此外，通过一致性指数（C-index）、受试者操作特征曲线下面积（AUC）和校准曲线证实，所建立的列线图模型对PSCCTh预后具有良好的一致性和区分度。
我们的研究表明，年龄、EOD、T分期、N分期和治疗可能与PSCCTh患者的OS和DSS相关。重要的是，我们使用年龄、T分期、N分期和治疗等参数构建的列线图预测模型可能有助于医生评估患者的预后，并为PSCCTh提供精确治疗。
