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印度北部一家农村三级医疗保健中心女性慢性阻塞性肺疾病患者的代谢综合征及其相关因素

Metabolic Syndrome and Its Correlates Among Female Chronic Obstructive Pulmonary Disease Patients at a Rural Tertiary Health Care Center in Northern India.

作者信息

Roy Ruchira, Gautam Aditya K, Singh Naresh P, Kumar Adesh

机构信息

Department of Respiratory Medicine, Uttar Pradesh University of Medical Sciences, Etawah, IND.

Department of Community Medicine, Uttar Pradesh University of Medical Sciences, Etawah, IND.

出版信息

Cureus. 2022 Aug 31;14(8):e28611. doi: 10.7759/cureus.28611. eCollection 2022 Aug.

Abstract

BACKGROUND

Chronic obstructive pulmonary disease (COPD) is a lung disease that is thought to result from chronic inflammation that may affect other organ systems. Similarly, metabolic syndrome includes central obesity, hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL-C), hyperglycemia, and hypertension. The prevalence of metabolic syndrome and its associated factors among female COPD patients in northern India needs to be evaluated.

AIM AND OBJECTIVES

To find the prevalence of metabolic syndrome and its correlates among female chronic obstructive pulmonary disease patients at a rural tertiary health care center in northern India.

MATERIALS AND METHODS

A cross-sectional study was conducted between January 2019 and June 2020 at a rural tertiary health care center in northern India. The female patients who presented with symptoms of COPD and fulfilled the inclusion criteria were included and classified by Global Initiative for Chronic Obstructive Lung Disease (GOLD 2020) guideline while the clinical diagnosis of metabolic syndrome was made according to National Cholesterol Education Program: Adult Treatment Panel III (NCEP: ATP III) criteria.

RESULTS

A total of 210 female COPD patients were included, the mean age of patients who had metabolic syndrome was 63.38±10.54 years. Metabolic syndrome was diagnosed in 60.48% of patients. There was a significant difference between female COPD patients with and without metabolic syndrome regarding body weight, BMI (body mass index), waist circumference, systolic blood pressure (SBP) and diastolic blood pressure (DBP), blood sugar, serum triglyceride, serum HDL-C. Whereas no significant difference was found between patients with and without metabolic syndrome group regarding smoking exposure, biomass fuel exposure, duration of biomass fuel exposure, mMRC (modified Medical Research Council) grading of breathlessness, GOLD grading of airflow limitation, route and duration of corticosteroid used. In our study, we also found a significant association between the severity of airflow limitation of COPD with the duration of biomass fuel exposure and BMI. Also, there was a significant association between biomass fuel exposure and the presence of cough in female COPD patients.

CONCLUSION

Metabolic syndrome is a prevalent entity in female COPD patients among the northern Indian population. Body weight, BMI, waist circumference, SBP, DBP, fasting blood sugar, serum triglyceride, and serum HDL-C have a significant impact on developing metabolic syndrome in female COPD patients. Duration of biomass fuel exposure and BMI also have a significant impact on the severity of airflow limitation in female COPD patients. So early detection and treatment of parameters of metabolic syndrome are important to reduce complications.

摘要

背景

慢性阻塞性肺疾病(COPD)是一种肺部疾病,被认为是由可能影响其他器官系统的慢性炎症引起的。同样,代谢综合征包括中心性肥胖、高甘油三酯血症、低高密度脂蛋白胆固醇(HDL-C)、高血糖和高血压。印度北部女性COPD患者中代谢综合征的患病率及其相关因素需要进行评估。

目的

在印度北部一家农村三级医疗保健中心,了解女性慢性阻塞性肺疾病患者中代谢综合征的患病率及其相关因素。

材料与方法

2019年1月至2020年6月在印度北部一家农村三级医疗保健中心进行了一项横断面研究。纳入出现COPD症状并符合纳入标准的女性患者,并根据慢性阻塞性肺疾病全球倡议(GOLD 2020)指南进行分类,同时根据美国国家胆固醇教育计划:成人治疗小组III(NCEP:ATP III)标准进行代谢综合征的临床诊断。

结果

共纳入210例女性COPD患者,患有代谢综合征的患者平均年龄为63.38±10.54岁。60.48%的患者被诊断为代谢综合征。患有和未患有代谢综合征的女性COPD患者在体重、BMI(体重指数)、腰围、收缩压(SBP)和舒张压(DBP)、血糖、血清甘油三酯、血清HDL-C方面存在显著差异。而在吸烟暴露、生物质燃料暴露、生物质燃料暴露持续时间、改良医学研究委员会(mMRC)呼吸困难分级、气流受限的GOLD分级、使用皮质类固醇的途径和持续时间方面,患有和未患有代谢综合征的患者组之间未发现显著差异。在我们的研究中,我们还发现COPD气流受限的严重程度与生物质燃料暴露持续时间和BMI之间存在显著关联。此外,生物质燃料暴露与女性COPD患者咳嗽的存在之间存在显著关联。

结论

代谢综合征在印度北部人群的女性COPD患者中是一种普遍存在的情况。体重、BMI、腰围、SBP、DBP、空腹血糖、血清甘油三酯和血清HDL-C对女性COPD患者发生代谢综合征有显著影响。生物质燃料暴露持续时间和BMI对女性COPD患者气流受限的严重程度也有显著影响。因此,早期检测和治疗代谢综合征参数对于减少并发症很重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/8c88/9523432/84495cc1ca4f/cureus-0014-00000028611-i01.jpg

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