Yin Hong-Lei, Yin Shi-Qi, Lin Qing-Yan, Xu Ying, Xu Hong-Wei, Liu Tao
Department of Respiratory Medicine, Heilongjiang Provincial Hospital Department of Respiratory Medicine, Heilongjiang Electric Power Hospital, Harbin, Heilongjiang, China.
Medicine (Baltimore). 2017 May;96(19):e6836. doi: 10.1097/MD.0000000000006836.
This study compares the prevalence rates of comorbidities between chronic obstructive pulmonary disease (COPD) and non-COPD control patients reported in literature.
Literature was searched in several electronic databases. After the selection of studies by following précised eligibility criteria, meta-analyses of odds ratios (ORs) were carried out with subgroup and sensitivity analyses under random effects model.
Eleven studies (47,695,183 COPD and 47,924,876 non-COPD control patients' data) were used for meta-analysis. Average age of COPD patients was 66.66 ± 8.72 years of whom 55.4 ± 11.9% were males. The prevalence of cardiovascular comorbidities [OR 1.90, 95% confidence interval (95% CI) 1.59-2.28; P < .00001], cerebrovascular comorbidities (OR 1.84, 95% CI 1.47-2.31; P < .00001), hypertension (OR 1.45, 95% CI 1.31-1.61; P < .00001), diabetes mellitus (OR 1.22, 95% CI 1.07-1.38; P = .003), neurological and psychiatric disorders (OR 1.78, 95% CI 1.48-2.14; P < .00001), gut and renal disorders (OR 1.96, 95% CI 1.43-2.68; P < .00001), musculoskeletal disorders (OR 1.51, 95% CI 1.27-1.78; P < .00001), non-COPD respiratory comorbidities (OR 2.81, 95% CI 2.52-3.14; P < .00001), and cancer (OR 1.67, 95% CI 1.25-2.23; P = .0005) were significantly higher in COPD patients than in non-COPD controls.
COPD is associated with significantly higher comorbidities than in other diseases that should be taken into consideration in COPD control strategies.
本研究比较了文献报道的慢性阻塞性肺疾病（COPD）患者与非COPD对照患者的合并症患病率。
在多个电子数据库中检索文献。按照精确的纳入标准选择研究后，采用随机效应模型对优势比（OR）进行荟萃分析，并进行亚组分析和敏感性分析。
11项研究（47,695,183例COPD患者和47,924,876例非COPD对照患者的数据）用于荟萃分析。COPD患者的平均年龄为66.66±8.72岁，其中55.4±11.9%为男性。COPD患者心血管合并症[OR 1.90，95%置信区间（95%CI）1.59 - 2.28；P <.00001]、脑血管合并症（OR 1.84，95%CI 1.47 - 2.31；P <.00001）、高血压（OR 1.45，95%CI 1.31 - 1.61；P <.00001）、糖尿病（OR 1.22，95%CI 1.07 - 1.38；P =.003）、神经和精神障碍（OR 1.78，95%CI 1.48 - 2.14；P <.00001）、肠道和肾脏疾病（OR 1.96，95%CI 1.43 - 2.68；P <.00001）、肌肉骨骼疾病（OR 1.51，95%CI 1.27 - 1.78；P <.00001）、非COPD呼吸系统合并症（OR 2.81，95%CI 2.52 - 3.14；P <.00001）和癌症（OR 1.67，95%CI 1.25 - 2.23；P =.0005）的患病率显著高于非COPD对照组。
COPD患者的合并症显著高于其他疾病，在COPD控制策略中应予以考虑。
