一项关于特发性和遗传性肺动脉高压中BMI与功能分级及6分钟步行距离之间关联的初步研究：与雌激素代谢的可能关联。
A pilot study to examine association of BMI with functional class and 6 min walk distance in idiopathic and heritable PAH: Possible association with estrogen metabolism.
作者信息
MacLean Margaret R, Pandya Divya, Swietlik Emilia M, Denver Nina, Mair Kirsty, Morrell Nicholas W, Gräf Stefan
机构信息
Institute of Pharmacy and Biomedical Sciences University of Strathclyde Glasgow UK.
Department of Medicine University of Cambridge Cambridge UK.
出版信息
Pulm Circ. 2022 Jul 1;12(3):e12139. doi: 10.1002/pul2.12139. eCollection 2022 Jul.
Abstract
The hypothesis that a relationship exists between body mass index (BMI), functional class, and 6 min walk distance (6MWD) in Group 1-pulmonary arterial hypertension (PAH) was examined. Analysis of data from the UK National Cohort Study for heritable pulmonary arterial/idiopathic PAH suggests increased BMI is a predictor of worse functional class and shorter 6MWD; increased body-weight in mice and man may be associated with increased estrogen metabolism.
摘要
对第1组肺动脉高压（PAH）患者体重指数（BMI）、功能分级和6分钟步行距离（6MWD）之间关系的假设进行了检验。对英国遗传性肺动脉/特发性PAH国家队列研究的数据分析表明，BMI升高是功能分级较差和6MWD较短的预测指标；小鼠和人类体重增加可能与雌激素代谢增加有关。
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