Zhang Tiejun, Yang Yi, Sima Xiutian
Department of Neurosurgery, West China School of Medicine/West China Hospital, Sichuan University, Chengdu, China.
Chengdu Seventh People's Hospital, Chengdu, China.
Front Neurol. 2022 Sep 14;13:996631. doi: 10.3389/fneur.2022.996631. eCollection 2022.
The γ-aminobutyric acid type A receptors (GABAR) have been reported to contribute to the pathogenesis of epilepsy and the recurrence of chronic seizures. Genetic polymorphisms in and may confer a high risk of epilepsy and multiple drug resistance, but with conflicting results. We aimed to assess the association of rs2279020 and rs3219151 with epilepsy risk using a meta-analysis. The databases of Pubmed, Ovid, Web of Science, and China National Knowledge Infrastructure were searched. Summary odds ratios (ORs) and 95% confidence intervals (CIs) were computed to evaluate the association between the polymorphisms and epilepsy risk using a fixed- or random-effect model. Trial sequential analysis (TSA) was performed to assess the results of the meta-analysis. No significant association between the rs2279020 and rs3219151 and the risk of epilepsy was found in the Asian and Arabic populations. The negative results were also observed when comparing the rs2279020 and rs3219151 polymorphism to antiepileptic drug responsiveness. The trial sequential analysis confirmed the results of the meta-analysis. This meta-analysis suggests that rs2279020 and rs3219151 are not risk factors for the etiology of epilepsy and antiepileptic drug responsiveness in the Asian and Arabic populations.
据报道，A型γ-氨基丁酸受体（GABAR）与癫痫的发病机制及慢性癫痫发作的复发有关。[相关基因]的基因多态性可能会导致癫痫及多重耐药的高风险，但结果存在争议。我们旨在通过荟萃分析评估[相关基因]rs2279020和[另一相关基因]rs3219151与癫痫风险的关联。检索了PubMed、Ovid、科学网和中国知网数据库。采用固定效应或随机效应模型计算汇总比值比（OR）和95%置信区间（CI），以评估多态性与癫痫风险之间的关联。进行了试验序贯分析（TSA）以评估荟萃分析的结果。在亚洲和阿拉伯人群中，未发现[相关基因]rs2279020和[另一相关基因]rs3219151与癫痫风险之间存在显著关联。在比较[相关基因]rs2279020和[另一相关基因]rs3219151多态性与抗癫痫药物反应性时，也观察到了阴性结果。试验序贯分析证实了荟萃分析的结果。这项荟萃分析表明，在亚洲和阿拉伯人群中，[相关基因]rs2279020和[另一相关基因]rs3219151不是癫痫病因及抗癫痫药物反应性的危险因素。
