Wattanathamsan Onsurang, Pongrakhananon Varisa
Preclinical Toxicity and Efficacy Assessment of Medicines and Chemicals Research Unit, Chulalongkorn University, Bangkok, Thailand.
Department of Pharmacology and Physiology, Faculty of Pharmaceutical Sciences, Chulalongkorn University, Bangkok, Thailand.
Front Pharmacol. 2022 Sep 14;13:935493. doi: 10.3389/fphar.2022.935493. eCollection 2022.
The major cause of death in cancer patients is strongly associated with metastasis. While much remains to be understood, microtubule-associated proteins (MAPs) have shed light on metastatic progression's molecular mechanisms. In this review article, we focus on the role of MAPs in cancer aggressiveness, particularly cancer metastasis activity. Increasing evidence has shown that a growing number of MAP member proteins might be fundamental regulators involved in altering microtubule dynamics, contributing to cancer migration, invasion, and epithelial-to-mesenchymal transition. MAP types have been established according to their microtubule-binding site and function in microtubule-dependent activities. We highlight that altered MAP expression was commonly found in many cancer types and related to cancer progression based on available evidence. Furthermore, we discuss and integrate the relevance of MAPs and related molecular signaling pathways in cancer metastasis. Our review provides a comprehensive understanding of MAP function on microtubules. It elucidates how MAPs regulate cancer progression, preferentially in metastasis, providing substantial scientific information on MAPs as potential therapeutic targets and prognostic markers for cancer management.
癌症患者的主要死因与转移密切相关。尽管仍有许多有待了解之处，但微管相关蛋白（MAPs）已为转移进展的分子机制提供了线索。在这篇综述文章中，我们聚焦于MAPs在癌症侵袭性中的作用，尤其是癌症转移活性。越来越多的证据表明，越来越多的MAP成员蛋白可能是参与改变微管动力学、促进癌症迁移、侵袭以及上皮-间质转化的重要调节因子。MAPs类型已根据其微管结合位点以及在微管依赖性活动中的功能得以确立。基于现有证据，我们强调在许多癌症类型中普遍发现MAP表达改变，且其与癌症进展相关。此外，我们讨论并整合了MAPs及相关分子信号通路在癌症转移中的相关性。我们的综述提供了对MAPs在微管上功能的全面理解。它阐明了MAPs如何调节癌症进展，尤其是在转移方面，为将MAPs作为癌症治疗潜在靶点和预后标志物进行癌症管理提供了大量科学信息。
