Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, Beijing, China.
International Neuroscience Institute (China-INI), Xuanwu Hospital, Capital Medical University, Beijing, China.
Front Immunol. 2022 Sep 15;13:858924. doi: 10.3389/fimmu.2022.858924. eCollection 2022.
In recent years, with the current access in techniques, studies have significantly advanced the knowledge on meningeal immunity, revealing that the central nervous system (CNS) border acts as an immune landscape. The latest concept of meningeal immune system is a tertiary structure, which is a comprehensive overview of the meningeal immune system from macro to micro. We comprehensively reviewed recent advances in meningeal immunity, particularly the new understanding of the dural sinus and meningeal lymphatics. Moreover, based on the clues from the meningeal immunity, new insights were proposed into the dural arteriovenous fistula (DAVF) pathology, aiming to provide novel ideas for DAVF understanding.
近年来,随着技术的普及,脑膜免疫的研究取得了重大进展,揭示了中枢神经系统(CNS)边界作为免疫景观的作用。脑膜免疫系统的最新概念是一个三级结构,它从宏观到微观全面概述了脑膜免疫系统。我们全面回顾了脑膜免疫的最新进展,特别是对硬脑膜窦和脑膜淋巴管的新认识。此外,基于脑膜免疫的线索,我们对硬脑膜动静脉瘘(DAVF)的病理学提出了新的见解,旨在为 DAVF 的理解提供新的思路。