Hu Dongqing, Huo Yanming, Xue Ye, Feng Haixia, Sun Wei, Wang Huiqi, Wu Jing, Wang Xiaoyan
Department of Healthcare Security Management, Wangjing Hospital, China Academy of Chinese Medical Sciences, No. 6, Huajiadi Road, Chaoyang District, Beijing, 100102, China.
Tibetan Medicine Administration of Tibet Autonomous Region, Chengguan District, Lhasa, China.
Future Oncol. 2022 Oct;18(31):3537-3549. doi: 10.2217/fon-2022-0458. Epub 2022 Oct 3.
To evaluate the prognostic value of autophagy proteins in colorectal cancer (CRC). Six potential autophagy proteins were analyzed (Beclin-1, LC3A, LC3B, ULK1, ATG10 and p62). Hazard ratios (HRs) and 95% CIs for overall survival (OS) of CRC patients were calculated. A total of 20 studies were included. High expression of LC3B and p62 was associated with favorable OS (HR: 0.56, 95% CI: 0.40-0.80; HR: 0.76, 95% CI: 0.61-0.96), whereas high expression of Beclin-1 (HR: 1.47, 95% CI: 1.05-2.06) and ULK1 (HR: 1.92. 95% CI: 1.05-3.53) might predict worse OS in CRC patients. Beclin-1, LC3B and p62 might act as promising prognostic biomarkers for CRC. High LC3 and p62 expression can be reliable tools for metastasis prediction.
评估自噬蛋白在结直肠癌（CRC）中的预后价值。分析了六种潜在的自噬蛋白（Beclin-1、LC3A、LC3B、ULK1、ATG10和p62）。计算了结直肠癌患者总生存期（OS）的风险比（HRs）和95%置信区间（CIs）。共纳入20项研究。LC3B和p62的高表达与良好的总生存期相关（HR：0.56，95%CI：0.40-0.80；HR：0.76，95%CI：0.61-0.96），而Beclin-1（HR：1.47，95%CI：1.05-2.06）和ULK1（HR：1.92，95%CI：1.05-3.53）的高表达可能预示着结直肠癌患者的总生存期较差。Beclin-1、LC3B和p62可能是有前景的结直肠癌预后生物标志物。高LC3和p62表达可作为转移预测的可靠工具。
