Kidney Transplantation Unit, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Dietetics Teaching and Research Section, Henan Medical College, Xinzheng, People's Republic of China.
Ren Fail. 2022 Dec;44(1):1604-1614. doi: 10.1080/0886022X.2022.2128374.
Antibody-mediated rejection (AMR) has a strongly negative impact on long-term renal allograft survival. Currently, no recognized effective treatments are available, especially for chronic antibody-mediated rejection (CAMR). Donor-specific antibodies (DSAs) secreted by long-lived plasma cells and memory B cells are acknowledged as biomarkers of AMR. Nevertheless, it may be too late for the DSA routine examination production since DSAs may have binded to graft vascular endothelial cells through complement-dependent or complement-independent pathways. Therefore, methods to effectively monitor memory B cells and long-lived plasma cells and subsequently prevent DSA production are key to reducing the adverse effects of AMR. Therefore, this review mainly summarizes the production pathways of memory B cells and long-lived plasma cells and provides suggestions for the prevention of AMR after transplantation.
抗体介导的排斥反应 (AMR) 对长期肾移植的存活有强烈的负面影响。目前，尚无公认的有效治疗方法，尤其是慢性抗体介导的排斥反应 (CAMR)。由长寿浆细胞和记忆 B 细胞分泌的供体特异性抗体 (DSA) 被认为是 AMR 的生物标志物。然而，由于 DSA 可能已经通过补体依赖性或补体非依赖性途径与移植物血管内皮细胞结合，因此进行 DSA 常规检测可能为时已晚。因此，有效监测记忆 B 细胞和长寿浆细胞并防止 DSA 产生的方法是减少 AMR 不良影响的关键。因此，本综述主要总结了记忆 B 细胞和长寿浆细胞的产生途径，并为移植后 AMR 的预防提供了建议。
