Department of Biological and Biomedical Sciences, Aga Khan University, Karachi 74800, Pakistan.
National Institute on Aging, Baltimore, Maryland 21224, United States.
ACS Chem Neurosci. 2022 Oct 19;13(20):2934-2938. doi: 10.1021/acschemneuro.2c00482. Epub 2022 Oct 3.
With reports of diverse neurological deficits in the acute phase of COVID-19, there is a surge in neurological findings in Long-COVID─a protracted phase of SARS-CoV-2 infection. Very little is known regarding the pathogenic mechanisms of Neuro-COVID in the above two settings in the current pandemic. Herein, we hint toward the possible molecular mechanism that can contribute to the signs and symptoms of patients with neurological deficits and possible treatment and prevention modalities in the acute and chronic phases of COVID-19.
随着 COVID-19 急性期多种神经功能障碍的报告，SARS-CoV-2 感染的长期持续阶段——长新冠，出现了大量的神经学发现。目前大流行中，对于上述两种情况下的神经新冠的发病机制知之甚少。在此，我们提示了可能的分子机制，该机制可能导致具有神经功能障碍的患者出现症状和体征，以及在 COVID-19 的急性期和慢性期可能的治疗和预防方法。
