Sakai A, Kikuchi Y, Ohshima N, Hori M
Angiology. 1987 Jul;38(7):514-9. doi: 10.1177/000331978703800703.
The effects of pentoxifylline and prostaglandin E1 (PGE1) on red blood cell deformability during cold blood perfusion were studied by means of a filtration method. The deformability of normal red blood cells decreased with the temperature transition from 20 degrees to 15 degrees C (transit time: 3.5, 5.8, 25, and 99 seconds at 37 degrees, 20 degrees, 15 degrees, and 10 degrees C respectively). The effects of both pentoxifylline and PGE1 were not noticeable at 37 degrees C but became significant with hypothermia (5.0, 12, and 48 seconds at 20 degrees, 15 degrees, and 10 degrees C, respectively, in samples with pentoxifylline of 0.3 mg/ml; 5.3, 13, and 46 seconds at 20 degrees, 15 degrees, and 10 degrees C, respectively, in those with PGE1 of 40 ng/ml). The results in this study suggest that pretreatment of blood by pentoxifylline or PGE1 could improve coronary microcirculation perfused with cold blood cardioplegic solutions owing to significant improvement of the deformability of red blood cells.
采用过滤法研究了己酮可可碱和前列腺素E1（PGE1）在冷血灌注过程中对红细胞变形性的影响。正常红细胞的变形性随着温度从20℃降至15℃而降低（在37℃、20℃、15℃和10℃时的通过时间分别为3.5秒、5.8秒、25秒和99秒）。己酮可可碱和PGE1在37℃时的作用均不明显，但在低温时作用显著（在含有0.3mg/ml己酮可可碱的样本中，20℃、15℃和10℃时分别为5.0秒、12秒和48秒；在含有40ng/ml PGE1的样本中，20℃、15℃和10℃时分别为5.3秒、13秒和46秒）。本研究结果表明，己酮可可碱或PGE1对血液进行预处理可改善用冷血心脏停搏液灌注的冠状动脉微循环，因为红细胞变形性得到了显著改善。
