身体活动强度与帕金森病患者的认知功能和功能连接有关。
Physical activity intensity is associated with cognition and functional connectivity in Parkinson's disease.
机构信息
Department of Neurology, Keck School of Medicine, University of Southern California, Los Angeles, CA, 90089, USA; Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, 90089, USA.
Department of Psychology, University of Virginia, Charlottesville, VA, 22904, USA.
出版信息
Parkinsonism Relat Disord. 2022 Nov;104:7-14. doi: 10.1016/j.parkreldis.2022.09.005. Epub 2022 Sep 24.
BACKGROUND
Cognitive impairment is common in Parkinson's disease (PD) and often leads to dementia, with no effective treatment. Aging studies suggest that physical activity (PA) intensity has a positive impact on cognition and enhanced functional connectivity may underlie these benefits. However, less is known in PD. This cross-sectional study examined the relationship between PA intensity, cognitive performance, and resting state functional connectivity in PD and whether PA intensity influences the relationship between functional connectivity and cognitive performance.
METHODS
96 individuals with mild-moderate PD completed a comprehensive neuropsychological battery. Intensity of PA was objectively captured over a seven-day period using a wearable device (ActiGraph). Time spent in light and moderate intensity PA was determined based on standardized actigraphy cut points. Resting-state fMRI was assessed in a subset of 50 individuals to examine brain-wide functional connectivity.
RESULTS
Moderate intensity PA (MIPA), but not light PA, was associated with better global cognition, visuospatial function, memory, and executive function. Individuals who met the WHO recommendation of ≥150 min/week of MIPA demonstrated better global cognition, executive function, and visuospatial function. Resting-state functional connectivity associated with MIPA included a combination of brainstem, hippocampus, and regions in the frontal, cingulate, and parietal cortices, which showed higher connectivity across the brain in those achieving the WHO MIPA recommendation. Meeting this recommendation positively moderated the associations between identified functional connectivity and global cognition, visuospatial function, and language.
CONCLUSION
Encouraging MIPA, particularly the WHO recommendation of ≥150 min of MIPA/week, may represent an important prescription for PD cognition.
背景
认知障碍在帕金森病（PD）中很常见，并且常常导致痴呆，目前尚无有效的治疗方法。衰老研究表明，身体活动（PA）强度对认知有积极影响，增强的功能连接可能是这些益处的基础。但是，在 PD 中了解较少。这项横断面研究检查了 PD 中 PA 强度、认知表现和静息状态功能连接之间的关系，以及 PA 强度是否会影响功能连接与认知表现之间的关系。
方法
96 名轻度至中度 PD 患者完成了全面的神经心理学测试。使用可穿戴设备（ActiGraph）在七天的时间内客观地记录 PA 强度。根据标准化的动作计切点确定轻度和中度 PA 所花费的时间。在 50 名个体的亚组中评估静息状态 fMRI，以检查大脑的广泛功能连接。
结果
中度 PA（MIPA），而不是轻度 PA，与更好的整体认知、视空间功能、记忆和执行功能相关。达到世卫组织推荐的每周≥150 分钟 MIPA 的个体表现出更好的整体认知、执行功能和视空间功能。与 MIPA 相关的静息状态功能连接包括脑干、海马体以及额叶、扣带回和顶叶皮质中的区域的组合，在达到世卫组织 MIPA 推荐标准的个体中，整个大脑的连接性更高。达到此推荐标准可积极调节所确定的功能连接与整体认知、视空间功能和语言之间的关联。
结论
鼓励进行 MIPA，特别是达到世卫组织每周≥150 分钟 MIPA 的推荐标准，可能是 PD 认知的重要处方。
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