Lucas-Jiménez Olaia, Ojeda Natalia, Peña Javier, Díez-Cirarda María, Cabrera-Zubizarreta Alberto, Gómez-Esteban Juan Carlos, Gómez-Beldarrain María Ángeles, Ibarretxe-Bilbao Naroa
Department of Methods and Experimental Psychology, Faculty of Psychology and Education, University of Deusto, Bilbao, Spain.
OSATEK, MR Unit Hospital of Galdakao, Galdakao, Usansolo, Spain.
Parkinsonism Relat Disord. 2016 Dec;33:58-64. doi: 10.1016/j.parkreldis.2016.09.012. Epub 2016 Sep 10.
To assess whether functional neural connectivity is disrupted between the regions of the default mode network (DMN) in Parkinson's disease (PD) and how this connectivity is related to cognition, brain gray matter structure and white matter integrity and diffusivity.
Thirty-seven PD patients and 16 healthy controls were evaluated, using resting-state functional magnetic resonance imaging (MRI), T1-weighted MRI, diffusion-weighted imaging and a battery of cognitive tests. Functional connectivity between the regions of the DMN, specifically in the precuneus, anterior and posterior cingulate, medial prefrontal and temporal and inferior parietal cortices was assessed with seed-to-voxel connectivity; gray matter volume and white matter values were determined using voxel-based morphometry and tract-based spatial statistics.
Reduced functional connectivity was observed between the posterior cingulate and medial temporal lobe in PD. Lower cognitive performance, gray matter loss in posterior, medial temporal and parietal areas, and fractional anisotropy reduction in the white matter adjacent to DMN regions were also observed in PD patients compared with healthy controls. Lower DMN functional connectivity correlated with lower verbal and visual memory and visual abilities performance in PD. In addition, lower DMN functional connectivity correlated with lower gray matter volume in the posterior cingulate and precuneus, and with lower white matter fractional anisotropy of the inferior longitudinal and posterior cingulate fasciculi in PD.
By combining different neuroimaging techniques and cognitive data, results showed that functional connectivity alteration between the regions of the DMN is associated with lower cognitive performance and gray and white matter abnormalities in PD.
评估帕金森病（PD）患者默认模式网络（DMN）区域之间的功能神经连接是否中断，以及这种连接与认知、脑灰质结构、白质完整性和扩散性之间的关系。
对37例PD患者和16名健康对照者进行评估，采用静息态功能磁共振成像（MRI）、T1加权MRI、扩散加权成像和一系列认知测试。通过种子体素连接评估DMN区域之间的功能连接，特别是楔前叶、前扣带回和后扣带回、内侧前额叶、颞叶和顶下皮质；使用基于体素的形态学和基于束的空间统计学确定灰质体积和白质值。
PD患者后扣带回与内侧颞叶之间的功能连接减少。与健康对照者相比，PD患者还表现出较低的认知能力、后颞叶、内侧颞叶和顶叶区域的灰质损失，以及DMN区域附近白质的各向异性分数降低。PD患者中较低的DMN功能连接与较低的言语和视觉记忆以及视觉能力表现相关。此外，PD患者中较低的DMN功能连接与后扣带回和楔前叶的较低灰质体积，以及下纵束和后扣带回束的较低白质各向异性分数相关。
通过结合不同的神经影像学技术和认知数据，结果表明DMN区域之间的功能连接改变与PD患者较低的认知能力以及灰质和白质异常有关。
