Mohana K, Shanmugasundaram E R
J Nutr Sci Vitaminol (Tokyo). 1978;24(4):397-403. doi: 10.3177/jnsv.24.397.
The effect of pyridoxine deficiency on fat metabolism was studied using mutant strains of Aspergillus nidulans requiring pyridoxine for growth. Under pyridoxine deficiency the mutants exhibited increased levels of total lipid, sterols, phospholipids, and triacylglycerols. Total fatty acids were found to decrease with pyridoxine deficiency. An increase in saturated fatty acids and decrease in unsaturated fatty acids were seen with deficiency. Pyridoxine deficiency also increased lower carbon chain fatty acids. A possible involvement of pyridoxine in the elongation of fatty acid chain and in the desaturation of fatty acids in Aspergillus nidulans is suggested.
利用需要吡哆醇才能生长的构巢曲霉突变株研究了吡哆醇缺乏对脂肪代谢的影响。在吡哆醇缺乏的情况下，突变株的总脂质、固醇、磷脂和三酰甘油水平升高。发现总脂肪酸随着吡哆醇缺乏而减少。缺乏时可见饱和脂肪酸增加，不饱和脂肪酸减少。吡哆醇缺乏还增加了低碳链脂肪酸。这表明吡哆醇可能参与构巢曲霉脂肪酸链的延长和脂肪酸的去饱和作用。
