Fuyang People's Hospital, Anhui Medical University, Fuyang, China.
The Affiliated Hongqi Hospital, Mudanjiang Medical University, Mudanjiang, China.
Andrology. 2023 Jan;11(1):112-124. doi: 10.1111/andr.13307. Epub 2022 Oct 13.
Premature ejaculation (PE) is still a tough problem in drug treatment. Many clinical trials have proven that traditional Chinese medicine (TCM) has a significant effect in the treatment of PE. This article aims to provide the latest evidence for the efficacy and safety of TCM combined with selective serotonin reuptake inhibitors (SSRIs) in the treatment of PE.
We looked for randomized controlled trials (RCTs) from China National Knowledge Infrastructure, Wanfang, VIP Database, MEDLINE, PubMed, Web of Science, EMBASE, and Cochrane Library until June 30, 2022. STATA 15.1 software was used to analyze all data for this article. The quality of the included articles was evaluated using the Cochrane Reviewer's Handbook 5.3.
Finally, we selected 16 high-quality RCTs in our meta-analysis, which containing 889 patients. Meta-analysis suggested that, compared with SSRIs alone, combination of TCM with SSRIs increased significantly intravaginal ejaculation latencv time and the scores of ejaculation control ability, sexual life satisfaction, PE-related distress, and communication difficulties between partners related to PE. Also, there was no significant difference in adverse effects between the two groups. In addition, the results of publication bias test showed that no significant bias occurred.
The combined use of TCM and SSRIs has significant effect in the treatment of PE compared with SSRIs monotherapy and was generally well tolerated. Due to the small sample size, multicenter and large sample RCT is still needed in the future to further confirm the effectiveness and safety of TCM combined with SSRIs in the treatment of PE.
早泄（PE）仍然是药物治疗中的一个难题。许多临床试验已经证明，中医药（TCM）在治疗 PE 方面具有显著疗效。本文旨在为 TCM 联合选择性 5-羟色胺再摄取抑制剂（SSRIs）治疗 PE 的疗效和安全性提供最新证据。
我们在中国知网、万方、维普数据库、MEDLINE、PubMed、Web of Science、EMBASE 和 Cochrane Library 中检索了截至 2022 年 6 月 30 日的随机对照试验（RCT）。本文所有数据均采用 STATA 15.1 软件进行分析。使用 Cochrane 评论员手册 5.3 评估纳入文章的质量。
最终，我们的荟萃分析纳入了 16 项高质量 RCT，包含 889 名患者。荟萃分析表明，与 SSRIs 单药治疗相比，TCM 联合 SSRIs 可显著增加阴道内射精潜伏期时间和射精控制能力、性生活满意度、PE 相关困扰以及与 PE 相关的伴侣沟通困难的评分。此外，两组不良反应无显著差异。此外，发表偏倚检验结果表明无显著偏倚。
与 SSRIs 单药治疗相比，TCM 联合 SSRIs 治疗 PE 具有显著疗效，且一般耐受性良好。由于样本量小，未来仍需要多中心、大样本 RCT 进一步证实 TCM 联合 SSRIs 治疗 PE 的有效性和安全性。
