Klavins J V
Ann Clin Lab Sci. 1987 Jul-Aug;17(4):221-5.
Monoclonal antibodies to different markers can facilitate the diagnosis of T and B cell lymphomas, histiocytic lymphomas, malignant histiocytosis, and Hodgkin's disease. The B-cell lymphomas can be identified specifically by monoclonal anti-idiotype antibodies. Monoclonal antibodies are produced to defined markers like carcinoembryonic antigen (CEA) in colon carcinomas and other antigens especially of breast and ovarian carcinomas. When conjugated with 123I, monoclonal antibodies can be used to detect tumors by emission computerized tomography. Chromogranins are markers for neuroendocrine tumors, and they can be identified by monoclonal antibodies. More recently monoclonal antibodies have been produced to ras gene product p21, present in breast and colon carcinoma cells.
针对不同标志物的单克隆抗体有助于诊断T细胞和B细胞淋巴瘤、组织细胞淋巴瘤、恶性组织细胞增多症及霍奇金病。B细胞淋巴瘤可通过单克隆抗独特型抗体特异性识别。针对特定标志物如结肠癌中的癌胚抗原（CEA）以及其他抗原，尤其是乳腺癌和卵巢癌的抗原，可制备单克隆抗体。当与123I结合时，单克隆抗体可用于通过发射计算机断层扫描检测肿瘤。嗜铬粒蛋白是神经内分泌肿瘤的标志物，可通过单克隆抗体识别。最近，针对存在于乳腺癌和结肠癌细胞中的ras基因产物p21也制备出了单克隆抗体。
