白藜芦醇和α-硫辛酸联合对多囊卵巢综合征妇女体重和脂肪组成的影响：一项初步的初步研究。
Effects of a combination of resveratrol and alpha-lipoic acid on body weight and adipose composition in women with PCOS: a preliminary pilot study.
机构信息
Laboratory of Human Physiology, Phystech BioMed School, Faculty of Biological & Medical Physics, Moscow Institute of Physics and Technology (State University), Dolgoprudny, Moscow Region, Russia.
出版信息
Eur Rev Med Pharmacol Sci. 2022 Sep;26(18):6578-6582. doi: 10.26355/eurrev_202209_29757.
OBJECTIVE
Polycystic ovary syndrome is associated with reproductive and metabolic dysfunction; in fact, treatment aims in PCOS focus on optimizing healthy weight, improving underlying hormonal disturbances, preventing future reproductive and metabolic complications, and improving quality of life.
PATIENTS AND METHODS
This pilot study considered 8 overweight females (BMI > 30) in reproductive age with PCOS. Patients were treated with a galenical preparation mixture containing resveratrol and alpha-lipoic acid in association with vitamin D, B and folic acid for 12 weeks, after which anthropometric assessment was conducted.
RESULTS
After 12 weeks of treatment, BMI, anthropometry and bioimpedance parameters were all reduced in the treated patients compared to baseline.
CONCLUSIONS
The present nutraceutical combination resulted beneficial for improving the metabolic profile of women with PCOS, paving the way for new nutraceutical strategies for the management of metabolic disturbances in PCOS.
目的
多囊卵巢综合征与生殖和代谢功能障碍有关；事实上，多囊卵巢综合征的治疗重点是优化健康体重、改善潜在的激素紊乱、预防未来的生殖和代谢并发症，以及提高生活质量。
患者和方法
本研究纳入了 8 名超重的多囊卵巢综合征育龄期女性（BMI>30）。患者接受含有白藜芦醇和α-硫辛酸的复方制剂联合维生素 D、B 和叶酸治疗 12 周，然后进行人体测量评估。
结果
治疗 12 周后，与基线相比，治疗患者的 BMI、人体测量和生物阻抗参数均降低。
结论
本营养保健品组合可改善多囊卵巢综合征患者的代谢状况，为多囊卵巢综合征代谢紊乱的新营养保健品治疗策略铺平道路。
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