一种抑制表皮有丝分裂的五肽的分离与结构
Isolation and structure of an epidermal mitosis inhibiting pentapeptide.
作者信息
Reichelt K L, Elgjo K, Edminson P D
出版信息
Biochem Biophys Res Commun. 1987 Aug 14;146(3):1493-501. doi: 10.1016/0006-291x(87)90818-7.
PMID:3619940
Abstract
A mitosis inhibiting peptide pyroGlu-Glu-Asp-Ser-GlyOH has been isolated from mouse skin extracts. Both the biological and a synthetic peptide with the same structure reversibly inhibit epidermal mitoses in a curvilinear fashion after intraperitoneal injection. The two compounds are chromatographically identical.
摘要
一种有丝分裂抑制肽焦谷氨酸-谷氨酸-天冬氨酸-丝氨酸-甘氨酸已从小鼠皮肤提取物中分离出来。该生物肽和具有相同结构的合成肽在腹腔注射后均以曲线方式可逆地抑制表皮有丝分裂。这两种化合物在色谱上是相同的。
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