Köpf-Maier P, Köpf H
Arzneimittelforschung. 1987 May;37(5):532-4.
In the present study, the antitumor activity of some titanocene derivatives (C5H5)2TiX2 (I, X = Cl; II, X = Br; III, X = cis-OOCCH = CHCOOH; IV, X = p-SC6H4NH3+Cl-) was investigated against B16 melanoma and colon 38 carcinoma. Both tumors grew subcutaneously as solid tumors in mice. Substances were applied intraperitoneally either as single, triple or 5-fold injections. Against both tumors, satisfactory results were observed for the chloro, bromo and aminothiophenolato derivatives I, II and IV, resp. They reduced tumor growth by 60-80% to 40-20% of control values. These effects underline the antitumor potency of titanocene complexes and show that titanocene dihalides as well as titanocene derivatives containing hydrophilic ligands X are able to inhibit the growth of various solid experimental tumors.
在本研究中，研究了一些二茂钛衍生物（C5H5）2TiX2（I，X = Cl；II，X = Br；III，X =顺式 - OOCCH = CHCOOH；IV，X = p - SC6H4NH3 + Cl - ）对B16黑色素瘤和结肠38癌的抗肿瘤活性。两种肿瘤均以实体瘤形式在小鼠皮下生长。物质通过单次、三次或5倍注射腹腔内给药。对于氯、溴和氨基硫酚盐衍生物I、II和IV，分别观察到对两种肿瘤均有令人满意的结果。它们将肿瘤生长降低至对照值的60 - 80%至40 - 20%。这些效应强调了二茂钛配合物的抗肿瘤效力，并表明二茂钛二卤化物以及含有亲水性配体X的二茂钛衍生物能够抑制各种实体实验肿瘤的生长。
